Antibacterial activity after a single-dose of norfloxacin, ofloxacin and pipemidic acid detected in urine of volunteers

M. Cruciani, V. Monzillo, A. Navarra, C. Tinelli, E. Concia

Research output: Contribution to journalArticle

Abstract

Six healthy volunteers received in a triple-crossover design a single oral dose of norfloxacin, ofloxacin or pipemidic acid. Urine samples were collected during the 24 h following the administration and were tested for inhibitory and bactericidal activity against selected strains of Enterobacteriaceae and Pseudomonas aeruginosa. Norfloxacin and ofloxacin inhibited the urinary growth of sensitive strains during the 24 h of sampling time at dilutions much higher than those generally considered satisfactory. Nalidixic acid was less effective and did not achieve bactericidal activity against Ps. aeruginosa over the interval of 12 to 24 h.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalDrugs under Experimental and Clinical Research
Volume14
Issue number8
Publication statusPublished - 1988

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Pipemidic Acid
Norfloxacin
Ofloxacin
Pseudomonas aeruginosa
Volunteers
Urine
Nalidixic Acid
Enterobacteriaceae
Cross-Over Studies
Healthy Volunteers
Growth

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Antibacterial activity after a single-dose of norfloxacin, ofloxacin and pipemidic acid detected in urine of volunteers. / Cruciani, M.; Monzillo, V.; Navarra, A.; Tinelli, C.; Concia, E.

In: Drugs under Experimental and Clinical Research, Vol. 14, No. 8, 1988, p. 533-537.

Research output: Contribution to journalArticle

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