Abstract
Synergy between cefotaxime and desacetyl-cefotaxime was evaluated against 12 strains (9 Enterobacteriaceae and 3 Bacteroides fragilis) by the chequerboard technique. A 1:1 combination of cefotaxime and desacetyl-cefotaxime was synergistic against two-thirds of the 12 strains tested. The in vitro activity of the combination was compared with that of four other β-lactam antibiotics against 96 recent clinical isolates: 78 Enterobacteriaceae, 8 Haemophilus influenzae, 10 B. fragilis. The MICs of the combination for Gram-negative bacilli were similar to those of ceftazidime. Cefotaxime/desacetyl-cefotaxime was more active than cefotetan, cefonicid and piperacillin against Enterobacteriaceae and H. influenzae.
Original language | English |
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Pages (from-to) | 629-633 |
Number of pages | 5 |
Journal | Drugs under Experimental and Clinical Research |
Volume | 16 |
Issue number | 12 |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology (medical)
- Drug Discovery
- Pharmacology