Antibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria

Gianmaria Fabrizio Ferrazzano, Elisa Scioscia, Daniela Sateriale, Gabiria Pastore, Roberta Colicchio, Chiara Pagliuca, Tiziana Cantile, Brunella Alcidi, Marco Coda, Aniello Ingenito, Elena Scaglione, Annunziata Gaetana Cicatiello, Maria Grazia Volpe, Michele Di Stasio, Paola Salvatore, Caterina Pagliarulo

Research output: Contribution to journalArticlepeer-review


Aim: To evaluate the antimicrobial activity of hydroalcoholic extracts of pomegranate (Punica granatumL.) peel and juice, against the microorganisms considered the main etiologic agents of dental caries.

Methods: The values of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined againstStreptococcus mutansClarke ATCC® 25175™ strain andRothia dentocariosaclinical isolate.

Results: Peel extracts inhibit effectively the growth and survival ofS. mutansATCC 25175 strain andR. dentocariosaclinical isolate with MIC and MBC values of 10 μg/μl and 15 μg/μl, respectively. Furthermore, the pomegranate juice extract showed high inhibitory activity againstS. mutansATCC 25175 strain with a MIC value of 25 μg/μl and a MBC value of 40 μg/μl, whereas, againstR. dentocariosa, it has displayed a moderate inhibitory activity, with MIC and MBC values of 20 μg/μl and 140 μg/μl, respectively.

Conclusions: In vitro microbiological tests demonstrate that the hydroalcoholic extracts of pomegranate juice and peel are able to contrast the main cariogenic bacteria involved in tooth decay. Although being preliminary data, our results suggest that pomegranate polyphenolic compounds could represent a good adjuvant for the prevention and treatment of dental caries.

Original languageEnglish
Pages (from-to)2152749
JournalBioMed Research International
Publication statusPublished - 2017


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