TY - JOUR
T1 - Antibacterial and cytotoxic activities of wild mushroom Fomes fomentarius (L.) Fr., Polyporaceae
AU - Kolundžić, Marina
AU - Grozdanić, Nada D.
AU - Dodevska, Margarita
AU - Milenković, Marina
AU - Sisto, Francesca
AU - Miani, Alessandro
AU - Farronato, Giampietro
AU - Kundaković, Tatjana
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The antibacterial activity of cyclohexane, dichlormethane, methanol and aqueous extracts of tinder fungus Fomes fomentarius (L.) Fr (Polyporaceae) was tested against 9 bacterial strains (Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), as well as against 10 different clinical isolates and one reference strain of Helicobacter pylori. Minimal inhibitory concentrations (MICs) of all extracts against 9 bacterial strains were in the range of 125-250μg/ml. Methanol and aqueous extracts showed significant activity against H. pylori with MIC values between 4-32μg/ml. Also, cytotoxicity of tested extracts was significant. Aqueous extract was the most active one against HeLa cells with an IC50 8.31±1.18μg/ml and N87 cells with IC50 64.46±3.13μg/ml without any activity against normal MRC5 cell line (>200μg/ml).
AB - The antibacterial activity of cyclohexane, dichlormethane, methanol and aqueous extracts of tinder fungus Fomes fomentarius (L.) Fr (Polyporaceae) was tested against 9 bacterial strains (Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), as well as against 10 different clinical isolates and one reference strain of Helicobacter pylori. Minimal inhibitory concentrations (MICs) of all extracts against 9 bacterial strains were in the range of 125-250μg/ml. Methanol and aqueous extracts showed significant activity against H. pylori with MIC values between 4-32μg/ml. Also, cytotoxicity of tested extracts was significant. Aqueous extract was the most active one against HeLa cells with an IC50 8.31±1.18μg/ml and N87 cells with IC50 64.46±3.13μg/ml without any activity against normal MRC5 cell line (>200μg/ml).
KW - Antibacterial activity
KW - Cytotoxicity
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U2 - 10.1016/j.indcrop.2015.10.030
DO - 10.1016/j.indcrop.2015.10.030
M3 - Article
AN - SCOPUS:84947762628
VL - 79
SP - 110
EP - 115
JO - Industrial Crops and Products
JF - Industrial Crops and Products
SN - 0926-6690
ER -