Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid

Claudio Bassi, Roberta Fontana, Sergio Vesentini, Giorgio Cavallini, Luigi Marchiori, Massimo Falconi, Stefano Corra, Paolo Pederzoli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The majority of deaths in severe pancreatitis are the result of superinfection of necrotic tissue. The pathogen most commonly responsible for such infections is Escherichia coli. Antibiotic prophylaxis would appear a logical precaution. The antibacterial drugs of choice should possess two basic characteristics: they must be active against the flora responsible for the infections and must be capable of penetrating into the pancreas at adequate minimum inhibitory concentrations (MICs). Mezlocillin-which is active against E. coli-has been shown to possess the latter requisite, but achieving therapeutic concentrations requires administration at high doses. In the present study, pure human pancreatic fluid showed properties similar to those observed in the dog against E. coli (bacterial colony growth 100 times lower than in a control culture) and produced a 75 % reduction in mezlocillin MICs against this organism. These enhancing characteristics might make the commonly used doses sufficient for prophylactic purposes.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalInternational Journal of Pancreatology
Volume10
Issue number3-4
DOIs
Publication statusPublished - Nov 1991

Fingerprint

Mezlocillin
Microbial Sensitivity Tests
Human Activities
Escherichia coli
Escherichia coli Infections
Superinfection
Antibiotic Prophylaxis
Pancreatitis
Pancreas
Dogs
Growth
Infection
Pharmaceutical Preparations
Therapeutics

Keywords

  • Acute pancreatitis
  • Escherichia coli
  • infected pancreatic necrosis
  • mezlocillin
  • pancreatic juice

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

Cite this

Bassi, C., Fontana, R., Vesentini, S., Cavallini, G., Marchiori, L., Falconi, M., ... Pederzoli, P. (1991). Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid. International Journal of Pancreatology, 10(3-4), 293-297. https://doi.org/10.1007/BF02924168

Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid. / Bassi, Claudio; Fontana, Roberta; Vesentini, Sergio; Cavallini, Giorgio; Marchiori, Luigi; Falconi, Massimo; Corra, Stefano; Pederzoli, Paolo.

In: International Journal of Pancreatology, Vol. 10, No. 3-4, 11.1991, p. 293-297.

Research output: Contribution to journalArticle

Bassi, C, Fontana, R, Vesentini, S, Cavallini, G, Marchiori, L, Falconi, M, Corra, S & Pederzoli, P 1991, 'Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid', International Journal of Pancreatology, vol. 10, no. 3-4, pp. 293-297. https://doi.org/10.1007/BF02924168
Bassi, Claudio ; Fontana, Roberta ; Vesentini, Sergio ; Cavallini, Giorgio ; Marchiori, Luigi ; Falconi, Massimo ; Corra, Stefano ; Pederzoli, Paolo. / Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid. In: International Journal of Pancreatology. 1991 ; Vol. 10, No. 3-4. pp. 293-297.
@article{1478309e4a4c4dcea93c88cef3e1eee1,
title = "Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid",
abstract = "The majority of deaths in severe pancreatitis are the result of superinfection of necrotic tissue. The pathogen most commonly responsible for such infections is Escherichia coli. Antibiotic prophylaxis would appear a logical precaution. The antibacterial drugs of choice should possess two basic characteristics: they must be active against the flora responsible for the infections and must be capable of penetrating into the pancreas at adequate minimum inhibitory concentrations (MICs). Mezlocillin-which is active against E. coli-has been shown to possess the latter requisite, but achieving therapeutic concentrations requires administration at high doses. In the present study, pure human pancreatic fluid showed properties similar to those observed in the dog against E. coli (bacterial colony growth 100 times lower than in a control culture) and produced a 75 {\%} reduction in mezlocillin MICs against this organism. These enhancing characteristics might make the commonly used doses sufficient for prophylactic purposes.",
keywords = "Acute pancreatitis, Escherichia coli, infected pancreatic necrosis, mezlocillin, pancreatic juice",
author = "Claudio Bassi and Roberta Fontana and Sergio Vesentini and Giorgio Cavallini and Luigi Marchiori and Massimo Falconi and Stefano Corra and Paolo Pederzoli",
year = "1991",
month = "11",
doi = "10.1007/BF02924168",
language = "English",
volume = "10",
pages = "293--297",
journal = "International Journal of Gastrointestinal Cancer",
issn = "1537-3649",
publisher = "Humana Press",
number = "3-4",

}

TY - JOUR

T1 - Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid

AU - Bassi, Claudio

AU - Fontana, Roberta

AU - Vesentini, Sergio

AU - Cavallini, Giorgio

AU - Marchiori, Luigi

AU - Falconi, Massimo

AU - Corra, Stefano

AU - Pederzoli, Paolo

PY - 1991/11

Y1 - 1991/11

N2 - The majority of deaths in severe pancreatitis are the result of superinfection of necrotic tissue. The pathogen most commonly responsible for such infections is Escherichia coli. Antibiotic prophylaxis would appear a logical precaution. The antibacterial drugs of choice should possess two basic characteristics: they must be active against the flora responsible for the infections and must be capable of penetrating into the pancreas at adequate minimum inhibitory concentrations (MICs). Mezlocillin-which is active against E. coli-has been shown to possess the latter requisite, but achieving therapeutic concentrations requires administration at high doses. In the present study, pure human pancreatic fluid showed properties similar to those observed in the dog against E. coli (bacterial colony growth 100 times lower than in a control culture) and produced a 75 % reduction in mezlocillin MICs against this organism. These enhancing characteristics might make the commonly used doses sufficient for prophylactic purposes.

AB - The majority of deaths in severe pancreatitis are the result of superinfection of necrotic tissue. The pathogen most commonly responsible for such infections is Escherichia coli. Antibiotic prophylaxis would appear a logical precaution. The antibacterial drugs of choice should possess two basic characteristics: they must be active against the flora responsible for the infections and must be capable of penetrating into the pancreas at adequate minimum inhibitory concentrations (MICs). Mezlocillin-which is active against E. coli-has been shown to possess the latter requisite, but achieving therapeutic concentrations requires administration at high doses. In the present study, pure human pancreatic fluid showed properties similar to those observed in the dog against E. coli (bacterial colony growth 100 times lower than in a control culture) and produced a 75 % reduction in mezlocillin MICs against this organism. These enhancing characteristics might make the commonly used doses sufficient for prophylactic purposes.

KW - Acute pancreatitis

KW - Escherichia coli

KW - infected pancreatic necrosis

KW - mezlocillin

KW - pancreatic juice

UR - http://www.scopus.com/inward/record.url?scp=0026324263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026324263&partnerID=8YFLogxK

U2 - 10.1007/BF02924168

DO - 10.1007/BF02924168

M3 - Article

VL - 10

SP - 293

EP - 297

JO - International Journal of Gastrointestinal Cancer

JF - International Journal of Gastrointestinal Cancer

SN - 1537-3649

IS - 3-4

ER -