Antibiotic lock with vancomycin and urokinase can successfully treat colonized central venous catheters in pediatric cancer patients

Luigi De Sio, Alessandro Jenkner, Giuseppe Maria Milano, Ilaria Ilari, Paola Fidani, Aurora Castellano, Roberta Gareri, Alberto Donfrancesco

Research output: Contribution to journalArticle


We used an antibiotic lock technique with vancomycin in combination with urokinase in 10 consecutive eligible children with Gram-positive catheter-related bacteremia persisting after appropriate intravenous antibiotics. Treatment was successful in sterilizing all colonized central venous catheters, avoiding device removal and delay of further chemotherapy. The antibiotic lock technique may represent a safe and effective therapeutic option in patients with selected, uncomplicated catheter-related bacteremias resistant to systemic antimicrobial therapy, particularly when maintaining a venous access is mandatory.

Original languageEnglish
Pages (from-to)963-965
Number of pages3
JournalPediatric Infectious Disease Journal
Issue number10
Publication statusPublished - Oct 2004



  • Antibiotic lock technique
  • Central venous catheter
  • Gram-positive bacteremia
  • Pediatric cancer patients
  • Urokinase
  • Vancomycin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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