Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project

Maia De Luca, Daniele Donà, Carlotta Montagnani, Andrea Lo Vecchio, Marta Romanengo, Claudia Tagliabue, Chiara Centenari, Patrizia D'Argenio, Rebecca Lundin, Carlo Giaquinto, Luisa Galli, Alfredo Guarino, Susanna Esposito, Mike Sharland, Ann Versporten, Herman Goossens, Giangiacomo Nicolini

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Background Antimicrobials are the most commonly prescribed drugs. Many studies have evaluated antibiotic prescriptions in the paediatric outpatient but few studies describing the real antibiotic consumption in Italian children's hospitals have been published. Point-prevalence survey (PPS) has been shown to be a simple, feasible and reliable standardized method for antimicrobials surveillance in children and neonates admitted to the hospital. In this paper, we presented data from a PPS on antimicrobial prescriptions carried out in 7 large Italian paediatric institutions. Methods A 1-day PPS on antibiotic use in hospitalized neonates and children was performed in Italy between October and December 2012 as part of the Antibiotic Resistance and Prescribing in European Children project (ARPEC). Seven institutions in seven Italian cities were involved. The survey included all admitted patients less than 18 years of age present in the ward at 8:00 am on the day of the survey, who had at least one on-going antibiotic prescription. For all patients data about age, weight, underlying disease, antimicrobial agent, dose and indication for treatment were collected.Results The PPS was performed in 61 wards within 7 Italian institutions. A total of 899 patients were eligible and 349 (38.9%) had an on-going prescription for one or more antibiotics, with variable rates among the hospitals (25.7% - 53.8%). We describe antibiotic prescriptions separately in neonates ( = 30 days to

Original languageEnglish
Article numbere0154662
JournalPLoS One
Issue number5
Publication statusPublished - May 1 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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