Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project

Maia De Luca, Daniele Dona, Carlotta Montagnani, Andrea Lo Vecchio, M. Romanengo, Claudia Tagliabue, Chiara Centenari, Patrizia D'Argenio, Rebecca Lundin, C. Giaquinto, Luisa Galli, A. Guarino, Susanna Esposito, Mike Sharland, A. Versporten, H. Goossens, G. Nicolini

Research output: Contribution to journalArticle

Abstract

Background Antimicrobials are the most commonly prescribed drugs. Many studies have evaluated antibiotic prescriptions in the paediatric outpatient but few studies describing the real antibiotic consumption in Italian children's hospitals have been published. Point-prevalence survey (PPS) has been shown to be a simple, feasible and reliable standardized method for antimicrobials surveillance in children and neonates admitted to the hospital. In this paper, we presented data from a PPS on antimicrobial prescriptions carried out in 7 large Italian paediatric institutions. Methods A 1-day PPS on antibiotic use in hospitalized neonates and children was performed in Italy between October and December 2012 as part of the Antibiotic Resistance and Prescribing in European Children project (ARPEC). Seven institutions in seven Italian cities were involved. The survey included all admitted patients less than 18 years of age present in the ward at 8:00 am on the day of the survey, who had at least one on-going antibiotic prescription. For all patients data about age, weight, underlying disease, antimicrobial agent, dose and indication for treatment were collected.Results The PPS was performed in 61 wards within 7 Italian institutions. A total of 899 patients were eligible and 349 (38.9%) had an on-going prescription for one or more antibiotics, with variable rates among the hospitals (25.7% - 53.8%). We describe antibiotic prescriptions separately in neonates ( = 30 days to

Original languageEnglish
Article numbere0154662
JournalPLoS One
Volume11
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Antibiotic Prophylaxis
Microbial Drug Resistance
antibiotic resistance
Prescriptions
disease control
antibiotics
Anti-Bacterial Agents
anti-infective agents
neonates
Newborn Infant
Pediatrics
Hospitalized Child
Anti-Infective Agents
Italy
Surveys and Questionnaires
Outpatients
Weights and Measures
drugs
monitoring
dosage

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project. / De Luca, Maia; Dona, Daniele; Montagnani, Carlotta; Vecchio, Andrea Lo; Romanengo, M.; Tagliabue, Claudia; Centenari, Chiara; D'Argenio, Patrizia; Lundin, Rebecca; Giaquinto, C.; Galli, Luisa; Guarino, A.; Esposito, Susanna; Sharland, Mike; Versporten, A.; Goossens, H.; Nicolini, G.

In: PLoS One, Vol. 11, No. 5, e0154662, 01.05.2016.

Research output: Contribution to journalArticle

De Luca, M, Dona, D, Montagnani, C, Vecchio, AL, Romanengo, M, Tagliabue, C, Centenari, C, D'Argenio, P, Lundin, R, Giaquinto, C, Galli, L, Guarino, A, Esposito, S, Sharland, M, Versporten, A, Goossens, H & Nicolini, G 2016, 'Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project', PLoS One, vol. 11, no. 5, e0154662. https://doi.org/10.1371/journal.pone.0154662
De Luca, Maia ; Dona, Daniele ; Montagnani, Carlotta ; Vecchio, Andrea Lo ; Romanengo, M. ; Tagliabue, Claudia ; Centenari, Chiara ; D'Argenio, Patrizia ; Lundin, Rebecca ; Giaquinto, C. ; Galli, Luisa ; Guarino, A. ; Esposito, Susanna ; Sharland, Mike ; Versporten, A. ; Goossens, H. ; Nicolini, G. / Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project. In: PLoS One. 2016 ; Vol. 11, No. 5.
@article{e8e10c32a7414dc08d74d14ed802f57b,
title = "Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project",
abstract = "Background Antimicrobials are the most commonly prescribed drugs. Many studies have evaluated antibiotic prescriptions in the paediatric outpatient but few studies describing the real antibiotic consumption in Italian children's hospitals have been published. Point-prevalence survey (PPS) has been shown to be a simple, feasible and reliable standardized method for antimicrobials surveillance in children and neonates admitted to the hospital. In this paper, we presented data from a PPS on antimicrobial prescriptions carried out in 7 large Italian paediatric institutions. Methods A 1-day PPS on antibiotic use in hospitalized neonates and children was performed in Italy between October and December 2012 as part of the Antibiotic Resistance and Prescribing in European Children project (ARPEC). Seven institutions in seven Italian cities were involved. The survey included all admitted patients less than 18 years of age present in the ward at 8:00 am on the day of the survey, who had at least one on-going antibiotic prescription. For all patients data about age, weight, underlying disease, antimicrobial agent, dose and indication for treatment were collected.Results The PPS was performed in 61 wards within 7 Italian institutions. A total of 899 patients were eligible and 349 (38.9{\%}) had an on-going prescription for one or more antibiotics, with variable rates among the hospitals (25.7{\%} - 53.8{\%}). We describe antibiotic prescriptions separately in neonates ( = 30 days to",
author = "{De Luca}, Maia and Daniele Dona and Carlotta Montagnani and Vecchio, {Andrea Lo} and M. Romanengo and Claudia Tagliabue and Chiara Centenari and Patrizia D'Argenio and Rebecca Lundin and C. Giaquinto and Luisa Galli and A. Guarino and Susanna Esposito and Mike Sharland and A. Versporten and H. Goossens and G. Nicolini",
year = "2016",
month = "5",
day = "1",
doi = "10.1371/journal.pone.0154662",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project

AU - De Luca, Maia

AU - Dona, Daniele

AU - Montagnani, Carlotta

AU - Vecchio, Andrea Lo

AU - Romanengo, M.

AU - Tagliabue, Claudia

AU - Centenari, Chiara

AU - D'Argenio, Patrizia

AU - Lundin, Rebecca

AU - Giaquinto, C.

AU - Galli, Luisa

AU - Guarino, A.

AU - Esposito, Susanna

AU - Sharland, Mike

AU - Versporten, A.

AU - Goossens, H.

AU - Nicolini, G.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background Antimicrobials are the most commonly prescribed drugs. Many studies have evaluated antibiotic prescriptions in the paediatric outpatient but few studies describing the real antibiotic consumption in Italian children's hospitals have been published. Point-prevalence survey (PPS) has been shown to be a simple, feasible and reliable standardized method for antimicrobials surveillance in children and neonates admitted to the hospital. In this paper, we presented data from a PPS on antimicrobial prescriptions carried out in 7 large Italian paediatric institutions. Methods A 1-day PPS on antibiotic use in hospitalized neonates and children was performed in Italy between October and December 2012 as part of the Antibiotic Resistance and Prescribing in European Children project (ARPEC). Seven institutions in seven Italian cities were involved. The survey included all admitted patients less than 18 years of age present in the ward at 8:00 am on the day of the survey, who had at least one on-going antibiotic prescription. For all patients data about age, weight, underlying disease, antimicrobial agent, dose and indication for treatment were collected.Results The PPS was performed in 61 wards within 7 Italian institutions. A total of 899 patients were eligible and 349 (38.9%) had an on-going prescription for one or more antibiotics, with variable rates among the hospitals (25.7% - 53.8%). We describe antibiotic prescriptions separately in neonates ( = 30 days to

AB - Background Antimicrobials are the most commonly prescribed drugs. Many studies have evaluated antibiotic prescriptions in the paediatric outpatient but few studies describing the real antibiotic consumption in Italian children's hospitals have been published. Point-prevalence survey (PPS) has been shown to be a simple, feasible and reliable standardized method for antimicrobials surveillance in children and neonates admitted to the hospital. In this paper, we presented data from a PPS on antimicrobial prescriptions carried out in 7 large Italian paediatric institutions. Methods A 1-day PPS on antibiotic use in hospitalized neonates and children was performed in Italy between October and December 2012 as part of the Antibiotic Resistance and Prescribing in European Children project (ARPEC). Seven institutions in seven Italian cities were involved. The survey included all admitted patients less than 18 years of age present in the ward at 8:00 am on the day of the survey, who had at least one on-going antibiotic prescription. For all patients data about age, weight, underlying disease, antimicrobial agent, dose and indication for treatment were collected.Results The PPS was performed in 61 wards within 7 Italian institutions. A total of 899 patients were eligible and 349 (38.9%) had an on-going prescription for one or more antibiotics, with variable rates among the hospitals (25.7% - 53.8%). We describe antibiotic prescriptions separately in neonates ( = 30 days to

UR - http://www.scopus.com/inward/record.url?scp=84969542775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969542775&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0154662

DO - 10.1371/journal.pone.0154662

M3 - Article

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e0154662

ER -