Antibiotic prophylaxis in neutropenic children with acute leukemia: Do the presently available data really support this practice?

Carmelina Calitri; Eliana Ruberto; Elio Castagnola

doi:10.1111/ejh.13162

Antibiotic prophylaxis in neutropenic children with acute leukemia: Do the presently available data really support this practice?

Carmelina Calitri, Eliana Ruberto, Elio Castagnola

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Review article › peer-review

Abstract

Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.

Original language	English
Pages (from-to)	721-727
Number of pages	7
Journal	European Journal of Haematology
Volume	101
Issue number	6
DOIs	https://doi.org/10.1111/ejh.13162
Publication status	Published - Dec 2018

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@article{2595453240c14605b5a02ea2630d6ddb,

title = "Antibiotic prophylaxis in neutropenic children with acute leukemia: Do the presently available data really support this practice?",

abstract = "Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.",

author = "Carmelina Calitri and Eliana Ruberto and Elio Castagnola",

note = "{\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2018",

month = dec,

doi = "10.1111/ejh.13162",

language = "English",

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journal = "European Journal of Haematology",

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T1 - Antibiotic prophylaxis in neutropenic children with acute leukemia

T2 - Do the presently available data really support this practice?

AU - Calitri, Carmelina

AU - Ruberto, Eliana

AU - Castagnola, Elio

PY - 2018/12

Y1 - 2018/12

N2 - Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.

AB - Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.

U2 - 10.1111/ejh.13162

DO - 10.1111/ejh.13162

M3 - Review article

C2 - 30107054

VL - 101

SP - 721

EP - 727

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

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ER -