Abstract
Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.
| Original language | English |
|---|---|
| Pages (from-to) | 721-727 |
| Number of pages | 7 |
| Journal | European Journal of Haematology |
| Volume | 101 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2018 |
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Antibiotic prophylaxis in neutropenic children with acute leukemia : Do the presently available data really support this practice? / Calitri, Carmelina; Ruberto, Eliana; Castagnola, Elio.
In: European Journal of Haematology, Vol. 101, No. 6, 12.2018, p. 721-727.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Antibiotic prophylaxis in neutropenic children with acute leukemia
T2 - Do the presently available data really support this practice?
AU - Calitri, Carmelina
AU - Ruberto, Eliana
AU - Castagnola, Elio
N1 - © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2018/12
Y1 - 2018/12
N2 - Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.
AB - Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.
U2 - 10.1111/ejh.13162
DO - 10.1111/ejh.13162
M3 - Review article
C2 - 30107054
VL - 101
SP - 721
EP - 727
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 6
ER -