Antibiotic prophylaxis in neutropenic children with acute leukemia: Do the presently available data really support this practice?

Carmelina Calitri, Eliana Ruberto, Elio Castagnola

Research output: Contribution to journalReview article

Abstract

Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.

Original languageEnglish
Pages (from-to)721-727
Number of pages7
JournalEuropean Journal of Haematology
Volume101
Issue number6
DOIs
Publication statusPublished - Dec 2018

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Antibiotic Prophylaxis
Leukemia
Pediatrics
Anti-Bacterial Agents
Febrile Neutropenia
Fluoroquinolones
Microbial Drug Resistance
Fever
Placebos
Neoplasms

Cite this

Antibiotic prophylaxis in neutropenic children with acute leukemia : Do the presently available data really support this practice? / Calitri, Carmelina; Ruberto, Eliana; Castagnola, Elio.

In: European Journal of Haematology, Vol. 101, No. 6, 12.2018, p. 721-727.

Research output: Contribution to journalReview article

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