Antibiotic prophylaxis with teicoplanin in patients undergoing breast reconstruction with the transverse rectus abdominis myocutaneous flap

S. Franchellil, M. S. Leone, M. L. Rainero, M. Gipponi, F. Cafiero, R. Capuzzo, M. Costantini, P. L. Santi

Research output: Contribution to journalArticle

Abstract

The authors report the results of a randomized clinical trial of antibiotic prophylaxis for post-operative infection following breast reconstruction with the transverse rectus abdominis myocutaneous (TRAM) flap. The aim was to evaluate the efficacy and tolerability of short-term parenteral prophylaxis with teicoplanin; the endpoint of the study was the reduction of wound contamination assessed by microbiologic culture of drain fluid. From October 1990 to March 1992, 38 patients were recruited: 20 patients were included in the antibiotic prophylaxis arm (teicoplanin i.v. 400 mg one hour before operation and in the following 12 h plus 200 mg i.v. at 24 h after operation) and 18 patients in the control group. Analysis of drain fluid showed a higher contamination (15/18=83%) in the control group (Staphylococcus epidermides, Streptococcus alfa-emoliticus, Enterobacter aerogenes, Peptostreptococcus magnus) as compared to the prophylaxis arm with teicoplanin (2/20=10%) (Staphylococcus coagulase-negative) (p<0.0001). Moreover, 11 patients in the control group suffered from fever > 37.5° C as compared to one patient in the antibiotic prophylaxis group (p

Original languageEnglish
Pages (from-to)204-207
Number of pages4
JournalEuropean Journal of Plastic Surgery
Volume16
Issue number4-5
DOIs
Publication statusPublished - Sep 1993

Keywords

  • Antibiotic
  • Breast reconstruction
  • Myocutaneous flap
  • Prophylaxis

ASJC Scopus subject areas

  • Surgery

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    Franchellil, S., Leone, M. S., Rainero, M. L., Gipponi, M., Cafiero, F., Capuzzo, R., Costantini, M., & Santi, P. L. (1993). Antibiotic prophylaxis with teicoplanin in patients undergoing breast reconstruction with the transverse rectus abdominis myocutaneous flap. European Journal of Plastic Surgery, 16(4-5), 204-207. https://doi.org/10.1007/BF00175685