Abstract
The selective pressure generated by the use of antibiotics in clinical, veterinary, husbandry and agricultural practices is considered the major factor responsible for the emergence and spread of antibiotic-resistant bacteria since the beginning of the antibiotic era. However, recent studies have consistently demonstrated that acquired resistance traits can also be found in bacteria isolated from humans and wild animals not subjected to significant antibiotic exposure and living in remote areas of the planet. The scope of this article is to review and discuss the current knowledge on this intriguing phenomenon, which underscores the complexity of the mechanisms involved in the emergence and spread of antibiotic resistance and bears some relevant implications to the design and success of resistance-control strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 725-732 |
| Number of pages | 8 |
| Journal | Expert Review of Anti-Infective Therapy |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2008 |
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Keywords
- Antibiotic resistance
- Antibiotic use
- Commensal bacteria
- Remote human population
- Wild animal
ASJC Scopus subject areas
- Microbiology
- Virology
- Infectious Diseases
- Microbiology (medical)
Cite this
Antibiotic resistance in the absence of antimicrobial use : Mechanisms and implications. / Pallecchi, Lucia; Bartoloni, Alessandro; Paradisi, Franco; Rossolini, Gian Maria.
In: Expert Review of Anti-Infective Therapy, Vol. 6, No. 5, 10.2008, p. 725-732.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibiotic resistance in the absence of antimicrobial use
T2 - Mechanisms and implications
AU - Pallecchi, Lucia
AU - Bartoloni, Alessandro
AU - Paradisi, Franco
AU - Rossolini, Gian Maria
PY - 2008/10
Y1 - 2008/10
N2 - The selective pressure generated by the use of antibiotics in clinical, veterinary, husbandry and agricultural practices is considered the major factor responsible for the emergence and spread of antibiotic-resistant bacteria since the beginning of the antibiotic era. However, recent studies have consistently demonstrated that acquired resistance traits can also be found in bacteria isolated from humans and wild animals not subjected to significant antibiotic exposure and living in remote areas of the planet. The scope of this article is to review and discuss the current knowledge on this intriguing phenomenon, which underscores the complexity of the mechanisms involved in the emergence and spread of antibiotic resistance and bears some relevant implications to the design and success of resistance-control strategies.
AB - The selective pressure generated by the use of antibiotics in clinical, veterinary, husbandry and agricultural practices is considered the major factor responsible for the emergence and spread of antibiotic-resistant bacteria since the beginning of the antibiotic era. However, recent studies have consistently demonstrated that acquired resistance traits can also be found in bacteria isolated from humans and wild animals not subjected to significant antibiotic exposure and living in remote areas of the planet. The scope of this article is to review and discuss the current knowledge on this intriguing phenomenon, which underscores the complexity of the mechanisms involved in the emergence and spread of antibiotic resistance and bears some relevant implications to the design and success of resistance-control strategies.
KW - Antibiotic resistance
KW - Antibiotic use
KW - Commensal bacteria
KW - Remote human population
KW - Wild animal
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UR - http://www.scopus.com/inward/citedby.url?scp=55249092942&partnerID=8YFLogxK
U2 - 10.1586/14787210.6.5.725
DO - 10.1586/14787210.6.5.725
M3 - Article
VL - 6
SP - 725
EP - 732
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
SN - 1478-7210
IS - 5
ER -