Antibiotic treatment for pyelonephritis in children: Multicentre randomised controlled non-inferiority trial

Giovanni Montini; Antonella Toffolo; Pietro Zucchetta; Roberto Dall'Amico; Daniela Gobber; Alessandro Calderan; Francesca Maschio; Luigi Pavanello; Pier Paolo Molinari; Dante Scorrano; Sergio Zanchetta; Walburga Cassar; Paolo Brisotto; Andrea Corsini; Stefano Sartori; Liviana Da Dalt; Luisa Murer; Graziella Zacchello

doi:10.1136/bmj.39244.692442.55

Antibiotic treatment for pyelonephritis in children: Multicentre randomised controlled non-inferiority trial

Giovanni Montini, Antonella Toffolo, Pietro Zucchetta, Roberto Dall'Amico, Daniela Gobber, Alessandro Calderan, Francesca Maschio, Luigi Pavanello, Pier Paolo Molinari, Dante Scorrano, Sergio Zanchetta, Walburga Cassar, Paolo Brisotto, Andrea Corsini, Stefano Sartori, Liviana Da Dalt, Luisa Murer, Graziella Zacchello

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To compare the efficacy of oral antibiotic treatment alone with treatment started parenterally and completed orally in children with a first episode of acute pyelonephritis. Design: Multicentre, randomised controlled, open labelled, parallel group, non-inferiority trial. Setting: 28 paediatric units in north east Italy. Participants: 502 children aged 1 month to 9/l (SD 3.5) v 9.5x10⁹/l (SD 3.1), mean difference 0.3 (-0.3 to 0.9); percentage with sterile urine 185/186 v 203/204, risk difference-0.05% (-1.5% to 1.4%)). Similar results were found in the subgroup of 278 children with confirmed acute pyelonephritis on scintigraphy at study entry. Conclusions: Treatment with oral antibiotics is as effective as parenteral then oral treatment in the management of the first episode of clinical pyelonephritis in children. Trial registration: Clinical Trials NCT00161330.

Original language	English
Pages (from-to)	386-388
Number of pages	3
Journal	British Medical Journal
Volume	335
Issue number	7616
DOIs	https://doi.org/10.1136/bmj.39244.692442.55
Publication status	Published - Aug 25 2007

ASJC Scopus subject areas

Medicine(all)

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Montini, G., Toffolo, A., Zucchetta, P., Dall'Amico, R., Gobber, D., Calderan, A., Maschio, F., Pavanello, L., Molinari, P. P., Scorrano, D., Zanchetta, S., Cassar, W., Brisotto, P., Corsini, A., Sartori, S., Da Dalt, L., Murer, L., & Zacchello, G. (2007). Antibiotic treatment for pyelonephritis in children: Multicentre randomised controlled non-inferiority trial. British Medical Journal, 335(7616), 386-388. https://doi.org/10.1136/bmj.39244.692442.55

Antibiotic treatment for pyelonephritis in children : Multicentre randomised controlled non-inferiority trial. / Montini, Giovanni; Toffolo, Antonella; Zucchetta, Pietro; Dall'Amico, Roberto; Gobber, Daniela; Calderan, Alessandro; Maschio, Francesca; Pavanello, Luigi; Molinari, Pier Paolo; Scorrano, Dante; Zanchetta, Sergio; Cassar, Walburga; Brisotto, Paolo; Corsini, Andrea; Sartori, Stefano; Da Dalt, Liviana; Murer, Luisa; Zacchello, Graziella.

In: British Medical Journal, Vol. 335, No. 7616, 25.08.2007, p. 386-388.

Research output: Contribution to journal › Article › peer-review

Montini, G, Toffolo, A, Zucchetta, P, Dall'Amico, R, Gobber, D, Calderan, A, Maschio, F, Pavanello, L, Molinari, PP, Scorrano, D, Zanchetta, S, Cassar, W, Brisotto, P, Corsini, A, Sartori, S, Da Dalt, L, Murer, L & Zacchello, G 2007, 'Antibiotic treatment for pyelonephritis in children: Multicentre randomised controlled non-inferiority trial', British Medical Journal, vol. 335, no. 7616, pp. 386-388. https://doi.org/10.1136/bmj.39244.692442.55

Montini, Giovanni ; Toffolo, Antonella ; Zucchetta, Pietro ; Dall'Amico, Roberto ; Gobber, Daniela ; Calderan, Alessandro ; Maschio, Francesca ; Pavanello, Luigi ; Molinari, Pier Paolo ; Scorrano, Dante ; Zanchetta, Sergio ; Cassar, Walburga ; Brisotto, Paolo ; Corsini, Andrea ; Sartori, Stefano ; Da Dalt, Liviana ; Murer, Luisa ; Zacchello, Graziella. / Antibiotic treatment for pyelonephritis in children : Multicentre randomised controlled non-inferiority trial. In: British Medical Journal. 2007 ; Vol. 335, No. 7616. pp. 386-388.

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abstract = "Objective: To compare the efficacy of oral antibiotic treatment alone with treatment started parenterally and completed orally in children with a first episode of acute pyelonephritis. Design: Multicentre, randomised controlled, open labelled, parallel group, non-inferiority trial. Setting: 28 paediatric units in north east Italy. Participants: 502 children aged 1 month to 9/l (SD 3.5) v 9.5x109/l (SD 3.1), mean difference 0.3 (-0.3 to 0.9); percentage with sterile urine 185/186 v 203/204, risk difference-0.05% (-1.5% to 1.4%)). Similar results were found in the subgroup of 278 children with confirmed acute pyelonephritis on scintigraphy at study entry. Conclusions: Treatment with oral antibiotics is as effective as parenteral then oral treatment in the management of the first episode of clinical pyelonephritis in children. Trial registration: Clinical Trials NCT00161330.",

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AU - Dall'Amico, Roberto

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AU - Calderan, Alessandro

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AU - Pavanello, Luigi

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AU - Scorrano, Dante

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AU - Cassar, Walburga

AU - Brisotto, Paolo

AU - Corsini, Andrea

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AU - Da Dalt, Liviana

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AU - Zacchello, Graziella

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N2 - Objective: To compare the efficacy of oral antibiotic treatment alone with treatment started parenterally and completed orally in children with a first episode of acute pyelonephritis. Design: Multicentre, randomised controlled, open labelled, parallel group, non-inferiority trial. Setting: 28 paediatric units in north east Italy. Participants: 502 children aged 1 month to 9/l (SD 3.5) v 9.5x109/l (SD 3.1), mean difference 0.3 (-0.3 to 0.9); percentage with sterile urine 185/186 v 203/204, risk difference-0.05% (-1.5% to 1.4%)). Similar results were found in the subgroup of 278 children with confirmed acute pyelonephritis on scintigraphy at study entry. Conclusions: Treatment with oral antibiotics is as effective as parenteral then oral treatment in the management of the first episode of clinical pyelonephritis in children. Trial registration: Clinical Trials NCT00161330.

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