TY - JOUR
T1 - Antibiotic treatment for pyelonephritis in children
T2 - Multicentre randomised controlled non-inferiority trial
AU - Montini, Giovanni
AU - Toffolo, Antonella
AU - Zucchetta, Pietro
AU - Dall'Amico, Roberto
AU - Gobber, Daniela
AU - Calderan, Alessandro
AU - Maschio, Francesca
AU - Pavanello, Luigi
AU - Molinari, Pier Paolo
AU - Scorrano, Dante
AU - Zanchetta, Sergio
AU - Cassar, Walburga
AU - Brisotto, Paolo
AU - Corsini, Andrea
AU - Sartori, Stefano
AU - Da Dalt, Liviana
AU - Murer, Luisa
AU - Zacchello, Graziella
PY - 2007/8/25
Y1 - 2007/8/25
N2 - Objective: To compare the efficacy of oral antibiotic treatment alone with treatment started parenterally and completed orally in children with a first episode of acute pyelonephritis. Design: Multicentre, randomised controlled, open labelled, parallel group, non-inferiority trial. Setting: 28 paediatric units in north east Italy. Participants: 502 children aged 1 month to 9/l (SD 3.5) v 9.5x109/l (SD 3.1), mean difference 0.3 (-0.3 to 0.9); percentage with sterile urine 185/186 v 203/204, risk difference-0.05% (-1.5% to 1.4%)). Similar results were found in the subgroup of 278 children with confirmed acute pyelonephritis on scintigraphy at study entry. Conclusions: Treatment with oral antibiotics is as effective as parenteral then oral treatment in the management of the first episode of clinical pyelonephritis in children. Trial registration: Clinical Trials NCT00161330.
AB - Objective: To compare the efficacy of oral antibiotic treatment alone with treatment started parenterally and completed orally in children with a first episode of acute pyelonephritis. Design: Multicentre, randomised controlled, open labelled, parallel group, non-inferiority trial. Setting: 28 paediatric units in north east Italy. Participants: 502 children aged 1 month to 9/l (SD 3.5) v 9.5x109/l (SD 3.1), mean difference 0.3 (-0.3 to 0.9); percentage with sterile urine 185/186 v 203/204, risk difference-0.05% (-1.5% to 1.4%)). Similar results were found in the subgroup of 278 children with confirmed acute pyelonephritis on scintigraphy at study entry. Conclusions: Treatment with oral antibiotics is as effective as parenteral then oral treatment in the management of the first episode of clinical pyelonephritis in children. Trial registration: Clinical Trials NCT00161330.
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U2 - 10.1136/bmj.39244.692442.55
DO - 10.1136/bmj.39244.692442.55
M3 - Article
C2 - 17611232
AN - SCOPUS:34548379936
VL - 335
SP - 386
EP - 388
JO - British Medical Journal
JF - British Medical Journal
SN - 0959-8146
IS - 7616
ER -