Antibiotics as immunomodulant agents in COPD

Francesco Blasi, Marco Mantero, Stefano Aliberti

Research output: Contribution to journalArticlepeer-review

Abstract

It is widely accepted that some antibiotics have activities beyond their direct antibacterial effects. Macrolide is the antibiotic class with more convincing studies and evidence on its immunomodulatory and anti-inflammatory activities. Different clinical studies have shown that macrolide prophylaxis in patients with moderate-severe chronic obstructive pulmonary disease (COPD) can have a significant impact on the exacerbation rate reducing morbidity and, potentially, mortality of the disease. Other antibiotics, such as fluoroquinolones, demonstrate a variety of immunomodulatory effects but only few clinical data are available in COPD. New macrolide derivatives devoid of antibacterial activity have been synthetized. This review analyses the relevance of immunomodulatory and anti-inflammatory effects of antibiotics in the management of COPD.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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