Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures

Research output: Contribution to journalArticle

Abstract

Rasmussen's encephalitis (RE) is a rare condition characterized by drug-resistant seizures, recurrent status epilepticus and progressive lateralized neurological deterioration. There is evidence of autoimmune involvement in the pathogenesis. We investigated the presence of anti-GluR3 antibodies against peptides A and B in patients with RE (n=11), partial and generalized epilepsy (n=85) and other neurological diseases (n=30). The antibodies were specific for epilepsy and are thus not a marker of RE, while particularly high antibody titers characterized a subgroup of non-RE patients with "catastrophic" epilepsy. Antibodies against GluR3B peptide were significantly associated with frequent seizures compared to occasional or drug-controlled seizures.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalJournal of Neuroimmunology
Volume131
Issue number1-2
DOIs
Publication statusPublished - Oct 2002

Keywords

  • Antibodies against GluR3 peptide
  • Autoimmune reactivity
  • ELISA
  • Epilepsy
  • Rasmussen's encephalitis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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