Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions

C. Masini, D. D. Abeni, M. S. Cattaruzza, M. Capuano, C. Pedicelli, F. Cerimele, P. Pasquini, D. Cerimele, G. Fadda, P. Cattani

Research output: Contribution to journalArticle

Abstract

Background: Human herpesvirus 8 (HHV8) is considered as the infectious cofactor involved in the pathogenesis of Kaposi's sarcoma (KS). Its seroprevalence and modes of transmission in the general population are still undetermined. Objectives: We aimed to estimate the prevalence of HHV8 infection in a population at low risk for sexually transmitted diseases. Methods: We conducted a seroepidemiological survey on randomly selected individuals attending the dermatology department of a teaching hospital in Rome. Of 257 patients, 248 had their blood analysed for anti-HHV8 antibodies and 201 completed a standardized interview. Serological analysis was performed by an immunofluorescence assay able to detect antilytic antibodies. Results: We found an overall seroprevalence of 15.7% (95% confidence interval, CI 11.4-20.9%), similar in men and women (15.1% vs. 16.3%) and higher at older ages. Seropositivity was not related to sexual habits, while it was significantly associated with a history of hepatitis (seroprevalence 34.6%, adjusted odds ratio, OR 4.08, 95% CI 1.52-11.00) and with a diagnosis of non-melanoma skin cancer (42.9%, OR 4.20, 95% CI 1.26-14.02) or atypical naevi (35.3%, OR 6.21, 95% CI 1.85-20.86). Conclusions: Our data suggest that a non-sexual mode of transmission of HHV8 infection is plausible in an Italian population at low risk for sexually transmitted diseases and that other factors, besides differences in prevalence of HHV8 infection, may be involved in the epidemiology of classical KS. The unexpectedly high seropositivity rates in subjects with non-melanoma skin cancer and atypical naevi should be viewed with caution and require confirmation.

Original languageEnglish
Pages (from-to)484-490
Number of pages7
JournalBritish Journal of Dermatology
Volume143
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Human Herpesvirus 8
Herpesviridae Infections
Seroepidemiologic Studies
Antibodies
Kaposi's Sarcoma
Nevus
Skin Neoplasms
Sexually Transmitted Diseases
Dermatology
Teaching Hospitals
Hepatitis
Habits
Fluorescent Antibody Technique
Epidemiology
Odds Ratio
Confidence Intervals
Interviews
Population

Keywords

  • Human herpesvirus 8
  • Risk factors
  • Seroprevalence
  • Skin diseases

ASJC Scopus subject areas

  • Dermatology

Cite this

Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions. / Masini, C.; Abeni, D. D.; Cattaruzza, M. S.; Capuano, M.; Pedicelli, C.; Cerimele, F.; Pasquini, P.; Cerimele, D.; Fadda, G.; Cattani, P.

In: British Journal of Dermatology, Vol. 143, No. 3, 2000, p. 484-490.

Research output: Contribution to journalArticle

Masini, C, Abeni, DD, Cattaruzza, MS, Capuano, M, Pedicelli, C, Cerimele, F, Pasquini, P, Cerimele, D, Fadda, G & Cattani, P 2000, 'Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions', British Journal of Dermatology, vol. 143, no. 3, pp. 484-490. https://doi.org/10.1046/j.1365-2133.2000.03699.x
Masini, C. ; Abeni, D. D. ; Cattaruzza, M. S. ; Capuano, M. ; Pedicelli, C. ; Cerimele, F. ; Pasquini, P. ; Cerimele, D. ; Fadda, G. ; Cattani, P. / Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions. In: British Journal of Dermatology. 2000 ; Vol. 143, No. 3. pp. 484-490.
@article{1076c499974641a1b523f5174ae686f8,
title = "Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions",
abstract = "Background: Human herpesvirus 8 (HHV8) is considered as the infectious cofactor involved in the pathogenesis of Kaposi's sarcoma (KS). Its seroprevalence and modes of transmission in the general population are still undetermined. Objectives: We aimed to estimate the prevalence of HHV8 infection in a population at low risk for sexually transmitted diseases. Methods: We conducted a seroepidemiological survey on randomly selected individuals attending the dermatology department of a teaching hospital in Rome. Of 257 patients, 248 had their blood analysed for anti-HHV8 antibodies and 201 completed a standardized interview. Serological analysis was performed by an immunofluorescence assay able to detect antilytic antibodies. Results: We found an overall seroprevalence of 15.7{\%} (95{\%} confidence interval, CI 11.4-20.9{\%}), similar in men and women (15.1{\%} vs. 16.3{\%}) and higher at older ages. Seropositivity was not related to sexual habits, while it was significantly associated with a history of hepatitis (seroprevalence 34.6{\%}, adjusted odds ratio, OR 4.08, 95{\%} CI 1.52-11.00) and with a diagnosis of non-melanoma skin cancer (42.9{\%}, OR 4.20, 95{\%} CI 1.26-14.02) or atypical naevi (35.3{\%}, OR 6.21, 95{\%} CI 1.85-20.86). Conclusions: Our data suggest that a non-sexual mode of transmission of HHV8 infection is plausible in an Italian population at low risk for sexually transmitted diseases and that other factors, besides differences in prevalence of HHV8 infection, may be involved in the epidemiology of classical KS. The unexpectedly high seropositivity rates in subjects with non-melanoma skin cancer and atypical naevi should be viewed with caution and require confirmation.",
keywords = "Human herpesvirus 8, Risk factors, Seroprevalence, Skin diseases",
author = "C. Masini and Abeni, {D. D.} and Cattaruzza, {M. S.} and M. Capuano and C. Pedicelli and F. Cerimele and P. Pasquini and D. Cerimele and G. Fadda and P. Cattani",
year = "2000",
doi = "10.1046/j.1365-2133.2000.03699.x",
language = "English",
volume = "143",
pages = "484--490",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Blackwell Publishing Ltd",
number = "3",

}

TY - JOUR

T1 - Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions

AU - Masini, C.

AU - Abeni, D. D.

AU - Cattaruzza, M. S.

AU - Capuano, M.

AU - Pedicelli, C.

AU - Cerimele, F.

AU - Pasquini, P.

AU - Cerimele, D.

AU - Fadda, G.

AU - Cattani, P.

PY - 2000

Y1 - 2000

N2 - Background: Human herpesvirus 8 (HHV8) is considered as the infectious cofactor involved in the pathogenesis of Kaposi's sarcoma (KS). Its seroprevalence and modes of transmission in the general population are still undetermined. Objectives: We aimed to estimate the prevalence of HHV8 infection in a population at low risk for sexually transmitted diseases. Methods: We conducted a seroepidemiological survey on randomly selected individuals attending the dermatology department of a teaching hospital in Rome. Of 257 patients, 248 had their blood analysed for anti-HHV8 antibodies and 201 completed a standardized interview. Serological analysis was performed by an immunofluorescence assay able to detect antilytic antibodies. Results: We found an overall seroprevalence of 15.7% (95% confidence interval, CI 11.4-20.9%), similar in men and women (15.1% vs. 16.3%) and higher at older ages. Seropositivity was not related to sexual habits, while it was significantly associated with a history of hepatitis (seroprevalence 34.6%, adjusted odds ratio, OR 4.08, 95% CI 1.52-11.00) and with a diagnosis of non-melanoma skin cancer (42.9%, OR 4.20, 95% CI 1.26-14.02) or atypical naevi (35.3%, OR 6.21, 95% CI 1.85-20.86). Conclusions: Our data suggest that a non-sexual mode of transmission of HHV8 infection is plausible in an Italian population at low risk for sexually transmitted diseases and that other factors, besides differences in prevalence of HHV8 infection, may be involved in the epidemiology of classical KS. The unexpectedly high seropositivity rates in subjects with non-melanoma skin cancer and atypical naevi should be viewed with caution and require confirmation.

AB - Background: Human herpesvirus 8 (HHV8) is considered as the infectious cofactor involved in the pathogenesis of Kaposi's sarcoma (KS). Its seroprevalence and modes of transmission in the general population are still undetermined. Objectives: We aimed to estimate the prevalence of HHV8 infection in a population at low risk for sexually transmitted diseases. Methods: We conducted a seroepidemiological survey on randomly selected individuals attending the dermatology department of a teaching hospital in Rome. Of 257 patients, 248 had their blood analysed for anti-HHV8 antibodies and 201 completed a standardized interview. Serological analysis was performed by an immunofluorescence assay able to detect antilytic antibodies. Results: We found an overall seroprevalence of 15.7% (95% confidence interval, CI 11.4-20.9%), similar in men and women (15.1% vs. 16.3%) and higher at older ages. Seropositivity was not related to sexual habits, while it was significantly associated with a history of hepatitis (seroprevalence 34.6%, adjusted odds ratio, OR 4.08, 95% CI 1.52-11.00) and with a diagnosis of non-melanoma skin cancer (42.9%, OR 4.20, 95% CI 1.26-14.02) or atypical naevi (35.3%, OR 6.21, 95% CI 1.85-20.86). Conclusions: Our data suggest that a non-sexual mode of transmission of HHV8 infection is plausible in an Italian population at low risk for sexually transmitted diseases and that other factors, besides differences in prevalence of HHV8 infection, may be involved in the epidemiology of classical KS. The unexpectedly high seropositivity rates in subjects with non-melanoma skin cancer and atypical naevi should be viewed with caution and require confirmation.

KW - Human herpesvirus 8

KW - Risk factors

KW - Seroprevalence

KW - Skin diseases

UR - http://www.scopus.com/inward/record.url?scp=0033796565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033796565&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2133.2000.03699.x

DO - 10.1046/j.1365-2133.2000.03699.x

M3 - Article

C2 - 10971318

AN - SCOPUS:0033796565

VL - 143

SP - 484

EP - 490

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 3

ER -