Anticorpi contro gli antigeni granulocitari nelle IBD: Dalla morfologia microscopica alla specificità antigenica

Translated title of the contribution: Antibodies anti granulocytic antigens in IBD: From microscopic morphology to antigenic specificity

Elsa Mainardi, A. Montanelli

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: ANCA (p-ANCA and x-ANCA) have been documented to occur in many inflammatory disorders. The specific ANCA antigens and the clinical correlation of a positive ANCA test in these disorders are still for the most part obscure. The aim of the present study was to investigate the prevalence of and the target antigens for ANCA in patients with IBD. Methods: 104 patients (67 age between 3-18 years, mean age 8+3 and 37 age between 25-70 years, mean age 48+15) clinically and hystopathologically diagnosed as: 67 ulcerative colitis, 16 Crohn' disease, 21 other colitis (7 indeterminate colitis) were enrolled in our study. ANCA were determined by ELISA and IIF methods. Results: We observed a good performance in terms of sensibility and specificity of ANCA, and a good correlation between the two methods used; as regard ELISA determination the antigen frequently found in our cases was lactoferrin (60%). Conclusions: Is still unclear the role of these "minor antigens" in the diagnosis and pathogenesis of IBD, but is clear that only morphologic evaluation is no more sufficient.

Translated title of the contributionAntibodies anti granulocytic antigens in IBD: From microscopic morphology to antigenic specificity
Original languageItalian
Pages (from-to)127-131
Number of pages5
JournalReumatismo
Volume58
Issue number2
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Rheumatology

Fingerprint Dive into the research topics of 'Antibodies anti granulocytic antigens in IBD: From microscopic morphology to antigenic specificity'. Together they form a unique fingerprint.

Cite this