Antibodies are forever: A study using 12-26-year-old expired antibodies

Maria C. Argentieri, Daniela Pilla, Alice Vanzati, Silvia Lonardi, Fabio Facchetti, Claudio Doglioni, Carlo Parravicini, Giorgio Cattoretti

Research output: Contribution to journalArticle

Abstract

Aims: The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label. Methods and results: Four independent laboratories tested a small number of diagnostic antibodies kept at +4°C for 12-26 years, and found them to work perfectly on routine histology sections. Conclusions: Diagnostic antibodies may have a workable half-life in excess of 10 years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.

Original languageEnglish
Pages (from-to)869-876
Number of pages8
JournalHistopathology
Volume63
Issue number6
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Antibody
  • Expiry date
  • Immunohistochemistry

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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    Argentieri, M. C., Pilla, D., Vanzati, A., Lonardi, S., Facchetti, F., Doglioni, C., Parravicini, C., & Cattoretti, G. (2013). Antibodies are forever: A study using 12-26-year-old expired antibodies. Histopathology, 63(6), 869-876. https://doi.org/10.1111/his.12225