Antibodies are forever: A study using 12-26-year-old expired antibodies

Maria C. Argentieri, Daniela Pilla, Alice Vanzati, Silvia Lonardi, Fabio Facchetti, Claudio Doglioni, Carlo Parravicini, Giorgio Cattoretti

Research output: Contribution to journalArticlepeer-review


Aims: The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label. Methods and results: Four independent laboratories tested a small number of diagnostic antibodies kept at +4°C for 12-26 years, and found them to work perfectly on routine histology sections. Conclusions: Diagnostic antibodies may have a workable half-life in excess of 10 years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.

Original languageEnglish
Pages (from-to)869-876
Number of pages8
Issue number6
Publication statusPublished - Dec 2013


  • Antibody
  • Expiry date
  • Immunohistochemistry

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine


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