Antibodies to 125I-glutamic acid decarboxylase in patients with stiff man syndrome

A. Vincent, L. M E Grimaldi, G. Martino, C. Davenport, I. Todd

Research output: Contribution to journalArticle

Abstract

Antibodies to glutamic acid decarboxylase (GAD) are found in about 40% of patients with stiff man syndrome. A new assay involving immunoprecipitation of 125I-glutamic acid decarboxylase was used to measure anti-GAD antibodies in 18 patients with stiff man syndrome. Of the eight serum samples from patients with stiff man syndrome, that had previously been found positive by immunoprecipitation of 35S-GAD, seven were strongly positive with 125I-GAD and one gave an equivocal result. Other serum samples from patients with stiff man syndrome and from controls were negative except one from a patient who had a thymoma, acquired neuromyotonia, and myasthenia gravis. Nine of 35 serum samples referred for testing were positive; in two of these the serum titre was 20-50 times higher than that in the CSF. This assay should prove useful in the diagnosis, management, and investigation of stiff man syndrome.

Original languageEnglish
Pages (from-to)395-397
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume62
Issue number4
Publication statusPublished - 1997

Keywords

  • Glutamic acid decarboxylase
  • Neuromyotonia
  • Stiff man syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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