Antibodies to cardiac Purkinje cells: Further characterization in autoimmune diseases and atrioventricular heart block

M. Obbiassi, A. Brucato, P. L. Meroni, A. Vismara, M. Lettino, F. Poloni, A. Finzi, M. G. Fenini, L. Rossi

Research output: Contribution to journalArticle

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Abstract

We confirmed the occurrence of IgG antibodies reacting with ox cardiac conducting tissue in the serum of some human subjects. These antibodies failed to react with all ox cardiac conducting tissue cells; they reacted only with the cells defined as Purkinje cells. Having checked 352 sera, we found that the prevalence of antibodies to Purkinje cells was 11% in normal subjects (no correlation with sex and age), 14% in systemic lupus erythematosus, 21% in rheumatoid arthritis, 18% in progressive systemic sclerosis, and 23% in Sjögren syndrome. In 50 patients with permanent pacemakers for chronic non-postinfarction atrioventricular (AV) block the prevalence was 30% (P = 0.008). In a selected set of 29 patients with clinically idiopathic AV block located at or below the level of the His bundle the prevalence was 34.5% (P = 0.006). The possible role of anti-Purkinje cell antibodies in autoimmune damage of cardiac conduction tissue is discussed.

Original languageEnglish
Pages (from-to)141-150
Number of pages10
JournalClinical Immunology and Immunopathology
Volume42
Issue number2
DOIs
Publication statusPublished - 1987

Fingerprint

Heart Block
Atrioventricular Block
Purkinje Cells
Autoimmune Diseases
Antibodies
Bundle of His
Diffuse Scleroderma
Serum
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Antibodies to cardiac Purkinje cells : Further characterization in autoimmune diseases and atrioventricular heart block. / Obbiassi, M.; Brucato, A.; Meroni, P. L.; Vismara, A.; Lettino, M.; Poloni, F.; Finzi, A.; Fenini, M. G.; Rossi, L.

In: Clinical Immunology and Immunopathology, Vol. 42, No. 2, 1987, p. 141-150.

Research output: Contribution to journalArticle

Obbiassi, M. ; Brucato, A. ; Meroni, P. L. ; Vismara, A. ; Lettino, M. ; Poloni, F. ; Finzi, A. ; Fenini, M. G. ; Rossi, L. / Antibodies to cardiac Purkinje cells : Further characterization in autoimmune diseases and atrioventricular heart block. In: Clinical Immunology and Immunopathology. 1987 ; Vol. 42, No. 2. pp. 141-150.
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