Antibodies to hepatitis c virus (hcv) and transaminase concentration in chronic haemodialysis patients: A study with second-generation assays

F. Fabrizi, G. Bacchini, G. Pontoriero, F. Locatelli, L. Raffaele, I. Guarnori, G. Erba

Research output: Contribution to journalArticlepeer-review

Abstract

We used first- and second-generation assays such as Ortho I, Ortho 2 and 4-RIBA to define prevalence and nsk factors for anti-HCV antibodies in haemodialysed patients. Forty-nine (24%) subjects were found to be anti-HCV positive. Anti-HCV positiv ity was related to duration of dialysis and past or current elevations of GOT and GPT; the frequency of transfused patients was greater in HCV-positive than in HCV-negative subjects; there were 31 patients (pre valence of 20%) with anti-HCV antibodies among non-transfused patients. These findings show that, tested by second-generation assays, HCV infection is detected more than twice as commonly in haemodia lysis patients and may be responsible for a significant proportion of liver disease in this clinical setting Acquisition of hepatitis C virus by dialysis patients is not only through blood transfusions but also secondary to hepatitis C virus presence within the unit itself.

Original languageEnglish
Pages (from-to)744-747
Number of pages4
JournalNephrology Dialysis Transplantation
Volume8
Issue number8
DOIs
Publication statusPublished - 1993

Keywords

  • Haemodialysis
  • Hepatitis C virus
  • Transaminase levels

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Fingerprint

Dive into the research topics of 'Antibodies to hepatitis c virus (hcv) and transaminase concentration in chronic haemodialysis patients: A study with second-generation assays'. Together they form a unique fingerprint.

Cite this