Antibodies to hepatitis C virus in primary biliary cirrhosis.

E. Bertolini, F. Marelli, P. Zermiani, P. M. Battezzati, M. Zuin, G. A. Moroni, M. Podda

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We investigated the prevalence of anti-HCV in 160 consecutive patients with primary biliary cirrhosis. By ELISA, 19 (12%) were positive, as compared to a 68% prevalence in 135 patients with chronic non-A, non-B hepatitis. Serum IgG levels were significantly higher in the anti-HCV positive group. By RIBA, seropositivity was confirmed for 4 patients, whereas 7 were indeterminate. A slight, non-significant reduction of life expectancy was found in anti-HCV positive patients. Until reliable and independent confirmatory tests become available, definitive conclusions on the importance of anti-HCV positivity in primary biliary cirrhosis are improper.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalArchives of virology. Supplementum
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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    Bertolini, E., Marelli, F., Zermiani, P., Battezzati, P. M., Zuin, M., Moroni, G. A., & Podda, M. (1992). Antibodies to hepatitis C virus in primary biliary cirrhosis. Archives of virology. Supplementum, 4, 205-209.