Antibodies to hepatocyte derived antigens and liver damage in patients after bone marrow transplantation.

R. M. Borzì, R. Meliconi, R. Conte, G. Bandini, P. Ricci, F. Miglio, A. Facchini, G. Gasbarrini

Research output: Contribution to journalArticle

Abstract

The follow-up sera from 33 patients who received allogenic bone marrow transplantation (BMT) were tested by ELISA for antibodies to liver derived antigens present in a macromolecular, lipid associated, protein complex (LSP). Anti-LSP were found in 20% of patients with graft-vs-host disease (1 with acute GVHD, 3 with chronic GVHD), but in none of the 13 patients without GVHD. Lymphocytotoxic antibodies (LCTA) were frequently detected with similar prevalence in patients with and without GVHD. In the 4 anti-LSP +ve cases, LCTA serum levels did not follow the trend of anti-LSP antibody levels. Liver biopsy was performed in 10 patients with clinical and biochemical sign of GVHD and showed features of hepatic GVHD in six cases; although piecemeal necrosis was present in 3 cases, anti-LSP were detected only in one patient. An anti-LSP response can be elicited in patients after BMT only during GVHD, with no relationship to LCTA and without a close association with signs of periportal hepatocyte damage.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalAllergologia et Immunopathologia
Volume19
Issue number2
Publication statusPublished - Mar 1991

ASJC Scopus subject areas

  • Immunology and Allergy

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