Antibodies to histones in infectious mononucleosis

Carlo Garzelli, Maria Manunta, Marina Incaprera, Agostino Bazzichi, Pier Giulio Conaldi, Giuseppe Falcone

Research output: Contribution to journalArticlepeer-review


A polyspecific human monoclonal (auto)antibody, isolated from a patient in the acute phase of infectious mononucleosis, was found to react with all subfractions (H1, H2A, H2B, H3 and H4) of histones. This finding prompted us to study the occurrence of antibodies to histones in sera of patients with infectious mononucleosis. It was found that IgM binding to histones was detectable both in control and patient sera; however, sera from patients showed binding values of IgM antibodies to histones significantly higher than those of healthy controls; moreover, both in control and patient groups anti-histone IgM activity was found to correlate with serum IgM concentration. These findings suggest that anti-histone IgM antibodies belong to the class of antibodies defined as "natural antibodies" and that their increase during infectious mononucleosis is due to Epstein-Barr virus-induced polyclonal B cell activation.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalImmunology Letters
Issue number2
Publication statusPublished - 1992


  • Anti-histone antibody
  • Autoimmunity
  • Epstein-Barr virus
  • Infectious mononucleosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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