Antibodies to hn-RNP protein A1 in systemic lupus erythematosus: Clinical association with Raynaud's phenomenon and esophageal dysmotility

C. Montecucco, R. Caporali, F. Cobianchi, C. Negri, G. C B Astaldi-Ricotti

Research output: Contribution to journalArticle

Abstract

Antibodies to recombinant hn-RNP protein A1 were found by ELISA in sera from 26 out of 67 unselected patients with systemic lupus erythematosus. A higher number of anti-A1 positive patients had Raynaud's phenomenon (50% vs 7%) and esophageal dysmotility (42% vs 5%) than the anti-A1 negative patients. All 8 patients with both Raynaud's phenomenon and esophageal dysmotility had a positive anti-A1 assay. No association was found with other clinical findings, nor with disease activity and treatment regimes. Anti-A1 antibodies did not correlate with anti-RNP and anti-Sm antibodies, which were present in 30% and 12% of the anti-A1 positive cases and in 22% and 7% of the anti-A1 negative cases, respectively. Our results indicate that antibodies to hn-RNP protein A1 may be associated with a subset of SLE patients with clinical features overlapping those of progressive systemic sclerosis and quite distinct from the group identified by anti-RNP antibodies.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalClinical and Experimental Rheumatology
Volume10
Issue number3
Publication statusPublished - 1992

Fingerprint

Esophageal Motility Disorders
Raynaud Disease
Systemic Lupus Erythematosus
Antibodies
Anti-Idiotypic Antibodies
Proteins
Diffuse Scleroderma
Enzyme-Linked Immunosorbent Assay
Serum

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Antibodies to hn-RNP protein A1 in systemic lupus erythematosus : Clinical association with Raynaud's phenomenon and esophageal dysmotility. / Montecucco, C.; Caporali, R.; Cobianchi, F.; Negri, C.; Astaldi-Ricotti, G. C B.

In: Clinical and Experimental Rheumatology, Vol. 10, No. 3, 1992, p. 223-227.

Research output: Contribution to journalArticle

@article{ca9f388bf25a496bad05e6ef347dba90,
title = "Antibodies to hn-RNP protein A1 in systemic lupus erythematosus: Clinical association with Raynaud's phenomenon and esophageal dysmotility",
abstract = "Antibodies to recombinant hn-RNP protein A1 were found by ELISA in sera from 26 out of 67 unselected patients with systemic lupus erythematosus. A higher number of anti-A1 positive patients had Raynaud's phenomenon (50{\%} vs 7{\%}) and esophageal dysmotility (42{\%} vs 5{\%}) than the anti-A1 negative patients. All 8 patients with both Raynaud's phenomenon and esophageal dysmotility had a positive anti-A1 assay. No association was found with other clinical findings, nor with disease activity and treatment regimes. Anti-A1 antibodies did not correlate with anti-RNP and anti-Sm antibodies, which were present in 30{\%} and 12{\%} of the anti-A1 positive cases and in 22{\%} and 7{\%} of the anti-A1 negative cases, respectively. Our results indicate that antibodies to hn-RNP protein A1 may be associated with a subset of SLE patients with clinical features overlapping those of progressive systemic sclerosis and quite distinct from the group identified by anti-RNP antibodies.",
author = "C. Montecucco and R. Caporali and F. Cobianchi and C. Negri and Astaldi-Ricotti, {G. C B}",
year = "1992",
language = "English",
volume = "10",
pages = "223--227",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",
number = "3",

}

TY - JOUR

T1 - Antibodies to hn-RNP protein A1 in systemic lupus erythematosus

T2 - Clinical association with Raynaud's phenomenon and esophageal dysmotility

AU - Montecucco, C.

AU - Caporali, R.

AU - Cobianchi, F.

AU - Negri, C.

AU - Astaldi-Ricotti, G. C B

PY - 1992

Y1 - 1992

N2 - Antibodies to recombinant hn-RNP protein A1 were found by ELISA in sera from 26 out of 67 unselected patients with systemic lupus erythematosus. A higher number of anti-A1 positive patients had Raynaud's phenomenon (50% vs 7%) and esophageal dysmotility (42% vs 5%) than the anti-A1 negative patients. All 8 patients with both Raynaud's phenomenon and esophageal dysmotility had a positive anti-A1 assay. No association was found with other clinical findings, nor with disease activity and treatment regimes. Anti-A1 antibodies did not correlate with anti-RNP and anti-Sm antibodies, which were present in 30% and 12% of the anti-A1 positive cases and in 22% and 7% of the anti-A1 negative cases, respectively. Our results indicate that antibodies to hn-RNP protein A1 may be associated with a subset of SLE patients with clinical features overlapping those of progressive systemic sclerosis and quite distinct from the group identified by anti-RNP antibodies.

AB - Antibodies to recombinant hn-RNP protein A1 were found by ELISA in sera from 26 out of 67 unselected patients with systemic lupus erythematosus. A higher number of anti-A1 positive patients had Raynaud's phenomenon (50% vs 7%) and esophageal dysmotility (42% vs 5%) than the anti-A1 negative patients. All 8 patients with both Raynaud's phenomenon and esophageal dysmotility had a positive anti-A1 assay. No association was found with other clinical findings, nor with disease activity and treatment regimes. Anti-A1 antibodies did not correlate with anti-RNP and anti-Sm antibodies, which were present in 30% and 12% of the anti-A1 positive cases and in 22% and 7% of the anti-A1 negative cases, respectively. Our results indicate that antibodies to hn-RNP protein A1 may be associated with a subset of SLE patients with clinical features overlapping those of progressive systemic sclerosis and quite distinct from the group identified by anti-RNP antibodies.

UR - http://www.scopus.com/inward/record.url?scp=0026552530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026552530&partnerID=8YFLogxK

M3 - Article

C2 - 1582066

AN - SCOPUS:0026552530

VL - 10

SP - 223

EP - 227

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 3

ER -