Antibodies to human T-lymphotropic retrovirus, HTLV-III, in patients with lymphoadenopathy syndrome and in individuals at risk for AIDS in Italy

P. Rossi, M. C. Sirianni, L. Contu

Research output: Contribution to journalArticlepeer-review

Abstract

An epidemiological survey on the presence of lymphoadenopathy syndrome (LAS) in six Italian cities, and its correlation to human T lymphotropic retrovirus III (HTLV-III) is reported. Serum samples of 9 patients with AIDS, 180 with LAS, and 272 from individuals at risk for these diseases were analyzed. The percentage of positive sera varied from 77% in AIDS, to 50.9-100% in LAS according to the different geographical areas and/or the various categories of people with LAS. The percentage of positive sera in individuals at risk for AIDS or LAS varied from 8.5% in homosexuals, 13.8% in drug abusers and 28.4% in haemophiliacs. No positive sera were observed among 660 normal individuals, relatives of patients with AIDS or LAS and in 114 patients suffering from immunological or infectious diseases. Sera were also negative in patients with classical Kaposi's sarcoma or T-cell chronic lymphocytic leukemia. These results strongly suggest that HTLV-III is the cause of AIDS and LAS. Since none of the 660 unselected normal adults were positive while a discrete percentage of people at risk for AIDS showed antibodies to HTLV-III, we may presume that this infection is also prevalent in the Italian categories in which AIDS and LAS are most likely to develop.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalImmunologia Clinica e Sperimentale
Volume3
Issue number4
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy

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