Antibodies to mitochondria in intrahepatic and extrahepatic cholestasis

S. R. Fargion, E. Del Ninno, G. Ronchi

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Antimitochondrial antibodies (AMA) are generally considered diagnostic markers of primary biliary cirrhosis. Mistilis (1973) has recently detected AMA in long standing extrahepatic biliary obstruction. In the present investigations 41 cases of intrahepatic cholestasis and 70 cases of extrahepatic biliary obstruction have been tested. Intrahepatic cholestasis included: 9 primary biliary cirrhosis, 2 benign idiopathic recurrent cholestasis, 2 acute liver failure, 16 viral hepatitis, 7 drug induced cholestasis, 5 post necrotic cirrhosis. Extrahepatic biliary obstruction was due to: gallstone in 37 cases, cancer in 18, stricture of biliary ducts in 9, biliary intestinal reflux in 6. In all groups the patients were divided according to the duration of the obstruction varying from 3 wk to 72 mth. AMA were tested by the immunofluorescence method according to Walker et al. (1965). Sera were assayed undiluted and at different dilutions, using both human and rat tissues. Fluorescein conjugated anti human gamma globulin and anti IgG were used. There was a high incidence (88.8%) of antimitochondrial antibodies in primary biliary cirrhosis, whereas in all other cases of intrahepatic cholestasis the test was negative. In extrahepatic obstruction only one patient was positive for AMA in long standing cholestasis.

Original languageEnglish
Pages (from-to)210-211
Number of pages2
JournalRendiconti di Gastro-Enterologia
Issue number3
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Medicine(all)


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