Antibodies to mitochondria in intrahepatic and extrahepatic cholestasis

S. R. Fargion, E. Del Ninno, G. Ronchi

Research output: Contribution to journalArticle

Abstract

Antimitochondrial antibodies (AMA) are generally considered diagnostic markers of primary biliary cirrhosis. Mistilis (1973) has recently detected AMA in long standing extrahepatic biliary obstruction. In the present investigations 41 cases of intrahepatic cholestasis and 70 cases of extrahepatic biliary obstruction have been tested. Intrahepatic cholestasis included: 9 primary biliary cirrhosis, 2 benign idiopathic recurrent cholestasis, 2 acute liver failure, 16 viral hepatitis, 7 drug induced cholestasis, 5 post necrotic cirrhosis. Extrahepatic biliary obstruction was due to: gallstone in 37 cases, cancer in 18, stricture of biliary ducts in 9, biliary intestinal reflux in 6. In all groups the patients were divided according to the duration of the obstruction varying from 3 wk to 72 mth. AMA were tested by the immunofluorescence method according to Walker et al. (1965). Sera were assayed undiluted and at different dilutions, using both human and rat tissues. Fluorescein conjugated anti human gamma globulin and anti IgG were used. There was a high incidence (88.8%) of antimitochondrial antibodies in primary biliary cirrhosis, whereas in all other cases of intrahepatic cholestasis the test was negative. In extrahepatic obstruction only one patient was positive for AMA in long standing cholestasis.

Original languageEnglish
Pages (from-to)210-211
Number of pages2
JournalRendiconti di Gastro-Enterologia
Volume6
Issue number3
Publication statusPublished - 1974

Fingerprint

Extrahepatic Cholestasis
Intrahepatic Cholestasis
Mitochondria
Cholestasis
Antibodies
Biliary Liver Cirrhosis
Chemical and Drug Induced Liver Injury
Acute Liver Failure
gamma-Globulins
Gallstones
Fluorescein
Fluorescent Antibody Technique
Pathologic Constriction
Fibrosis
Incidence
Serum
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antibodies to mitochondria in intrahepatic and extrahepatic cholestasis. / Fargion, S. R.; Del Ninno, E.; Ronchi, G.

In: Rendiconti di Gastro-Enterologia, Vol. 6, No. 3, 1974, p. 210-211.

Research output: Contribution to journalArticle

@article{6caed581c15f4e77b01e53e67dcdf414,
title = "Antibodies to mitochondria in intrahepatic and extrahepatic cholestasis",
abstract = "Antimitochondrial antibodies (AMA) are generally considered diagnostic markers of primary biliary cirrhosis. Mistilis (1973) has recently detected AMA in long standing extrahepatic biliary obstruction. In the present investigations 41 cases of intrahepatic cholestasis and 70 cases of extrahepatic biliary obstruction have been tested. Intrahepatic cholestasis included: 9 primary biliary cirrhosis, 2 benign idiopathic recurrent cholestasis, 2 acute liver failure, 16 viral hepatitis, 7 drug induced cholestasis, 5 post necrotic cirrhosis. Extrahepatic biliary obstruction was due to: gallstone in 37 cases, cancer in 18, stricture of biliary ducts in 9, biliary intestinal reflux in 6. In all groups the patients were divided according to the duration of the obstruction varying from 3 wk to 72 mth. AMA were tested by the immunofluorescence method according to Walker et al. (1965). Sera were assayed undiluted and at different dilutions, using both human and rat tissues. Fluorescein conjugated anti human gamma globulin and anti IgG were used. There was a high incidence (88.8{\%}) of antimitochondrial antibodies in primary biliary cirrhosis, whereas in all other cases of intrahepatic cholestasis the test was negative. In extrahepatic obstruction only one patient was positive for AMA in long standing cholestasis.",
author = "Fargion, {S. R.} and {Del Ninno}, E. and G. Ronchi",
year = "1974",
language = "English",
volume = "6",
pages = "210--211",
journal = "Rendiconti di Gastro-Enterologia",
issn = "0300-0877",
publisher = "L. Pozzi",
number = "3",

}

TY - JOUR

T1 - Antibodies to mitochondria in intrahepatic and extrahepatic cholestasis

AU - Fargion, S. R.

AU - Del Ninno, E.

AU - Ronchi, G.

PY - 1974

Y1 - 1974

N2 - Antimitochondrial antibodies (AMA) are generally considered diagnostic markers of primary biliary cirrhosis. Mistilis (1973) has recently detected AMA in long standing extrahepatic biliary obstruction. In the present investigations 41 cases of intrahepatic cholestasis and 70 cases of extrahepatic biliary obstruction have been tested. Intrahepatic cholestasis included: 9 primary biliary cirrhosis, 2 benign idiopathic recurrent cholestasis, 2 acute liver failure, 16 viral hepatitis, 7 drug induced cholestasis, 5 post necrotic cirrhosis. Extrahepatic biliary obstruction was due to: gallstone in 37 cases, cancer in 18, stricture of biliary ducts in 9, biliary intestinal reflux in 6. In all groups the patients were divided according to the duration of the obstruction varying from 3 wk to 72 mth. AMA were tested by the immunofluorescence method according to Walker et al. (1965). Sera were assayed undiluted and at different dilutions, using both human and rat tissues. Fluorescein conjugated anti human gamma globulin and anti IgG were used. There was a high incidence (88.8%) of antimitochondrial antibodies in primary biliary cirrhosis, whereas in all other cases of intrahepatic cholestasis the test was negative. In extrahepatic obstruction only one patient was positive for AMA in long standing cholestasis.

AB - Antimitochondrial antibodies (AMA) are generally considered diagnostic markers of primary biliary cirrhosis. Mistilis (1973) has recently detected AMA in long standing extrahepatic biliary obstruction. In the present investigations 41 cases of intrahepatic cholestasis and 70 cases of extrahepatic biliary obstruction have been tested. Intrahepatic cholestasis included: 9 primary biliary cirrhosis, 2 benign idiopathic recurrent cholestasis, 2 acute liver failure, 16 viral hepatitis, 7 drug induced cholestasis, 5 post necrotic cirrhosis. Extrahepatic biliary obstruction was due to: gallstone in 37 cases, cancer in 18, stricture of biliary ducts in 9, biliary intestinal reflux in 6. In all groups the patients were divided according to the duration of the obstruction varying from 3 wk to 72 mth. AMA were tested by the immunofluorescence method according to Walker et al. (1965). Sera were assayed undiluted and at different dilutions, using both human and rat tissues. Fluorescein conjugated anti human gamma globulin and anti IgG were used. There was a high incidence (88.8%) of antimitochondrial antibodies in primary biliary cirrhosis, whereas in all other cases of intrahepatic cholestasis the test was negative. In extrahepatic obstruction only one patient was positive for AMA in long standing cholestasis.

UR - http://www.scopus.com/inward/record.url?scp=0016247174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016247174&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 210

EP - 211

JO - Rendiconti di Gastro-Enterologia

JF - Rendiconti di Gastro-Enterologia

SN - 0300-0877

IS - 3

ER -