Antibodies to Rods and Rings

S. John Calise, Wendy C. Carcamo, Angela Ceribelli, Yasmany Dominguez, Minoru Satoh, Edward K L Chan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Rods and rings (RR) are distinct cytoplasmic structures known to be composed of at least two enzymes critical for pyrimidine and purine synthesis. Due to the considerable size of these rods (3-10 μm in length) and rings (2-5 μm in diameter), RR are likely comprised of other unidentified proteins that may be related to nucleotide metabolism. Inhibition of either of the two known enzymes, cytidine triphosphate synthase 1 (CTPS1) and inosine monophosphate dehydrogenase 2 (IMPDH2), induces formation of RR in all cell lines examined to date. Therefore, the function of RR is affiliated with nucleotide metabolism since RR have been found to form under conditions of increased intracellular cytidine triphosphate (CTP) and guanosine triphosphate (GTP) requirements, such as in highly metabolically active cells like embryonic stem cells. Autoantibodies to RR have been identified in hepatitis C virus (HCV) patients who have undergone treatment with pegylated interferon-α/ribavirin therapy (IFN/R), but not detected in untreated chronic HCV patients. Our data show that HCV patients with high titer anti-RR are more likely to be nonresponders or relapsers to IFN/R therapy.

Original languageEnglish
Title of host publicationAutoantibodies: Third Edition
PublisherElsevier B.V.
Pages161-168
Number of pages8
ISBN (Print)9780444563781
DOIs
Publication statusPublished - Dec 2013

Keywords

  • CTP
  • CTPS
  • GTP
  • Hepatitis C
  • IMPDH
  • IMPDH2
  • Interferon-alpha
  • Ribavirin
  • Rods and rings

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Antibodies to Rods and Rings'. Together they form a unique fingerprint.

  • Cite this

    Calise, S. J., Carcamo, W. C., Ceribelli, A., Dominguez, Y., Satoh, M., & Chan, E. K. L. (2013). Antibodies to Rods and Rings. In Autoantibodies: Third Edition (pp. 161-168). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-56378-1.00019-8