Antibodies to sulfatide and to chondroitin sulfate C in patients with chronic sensory neuropathy

Raffaello Nemni, Raffaello Fazio, Angelo Quattrini, Isabella Lorenzetti, Daniela Mamoli, Nicola Canal

Research output: Contribution to journalArticle

Abstract

Sera from eight of 25 patients with chronic sensory neuropathy had high titers of antibodies to sulfatide and chondroitin sulfate C or both. Preclearing of patients' sera with either sulfatide or chondroitin sulfate C revealed that in four patients the antisulfatide antibodies crossreacted with chondroitin sulfate C. By indirect immunohistochemistry sera reactive to sulfatide only had a different staining pattern from those reactive to both sulfatide and chondroitin sulfate C. By direct immunohistochemistry we found immunoglobulins bound to nerve fibers only in patients with serum antibodies against both sulfatide and chondroitin sulfate C. Our study provides evidence that antibodies to sulfatide and to chondroitin sulfate C differ in their fine specificity and are present in 30% of patients with chronic sensory neuropathy.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalJournal of Neuroimmunology
Volume43
Issue number1-2
DOIs
Publication statusPublished - 1993

Keywords

  • Antibodies
  • Axonal neuropathy
  • Chondroitin sulfate C
  • Sensory neuropathy
  • Sulfatide

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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