TY - JOUR
T1 - Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates
AU - Ansaldi, Filippo
AU - Zancolli, Marta
AU - Durando, Paolo
AU - Montomoli, Emanuele
AU - Sticchi, Laura
AU - Del Giudice, Giuseppe
AU - Icardi, Giancarlo
PY - 2010/6/7
Y1 - 2010/6/7
N2 - MF59 is already known to enhance the breadth of antibody response to mismatched influenza seasonal and avian strains. However, little is known on the effect of MF59 on immunogenicity of influenza vaccines when "apparent" good matching between circulating and vaccine strains exists. To this end, we compared the immune response elicited by MF59-adjuvanted or non-adjuvanted subunit vaccine, containing A/California/7/04(H3N2) strain, against circulating viruses isolated between 2004/2005 and 2006/2007 seasons, belonging to different clades. The advantage offered by MF59 in terms of higher immunogenicity, expressed as higher post-vaccination HI titres, is observable also against viruses showing antigenic and molecular pattern undistinguishable from vaccine strain, but it became even more evident as the antigenic and molecular distance between vaccine and circulating strains grew. These data show that seasonal influenza vaccine adjuvanted with MF59 can offer a stronger benefit as compared to non-adjuvanted vaccine in protecting against a broader range of virus strains circulating during the influenza season.
AB - MF59 is already known to enhance the breadth of antibody response to mismatched influenza seasonal and avian strains. However, little is known on the effect of MF59 on immunogenicity of influenza vaccines when "apparent" good matching between circulating and vaccine strains exists. To this end, we compared the immune response elicited by MF59-adjuvanted or non-adjuvanted subunit vaccine, containing A/California/7/04(H3N2) strain, against circulating viruses isolated between 2004/2005 and 2006/2007 seasons, belonging to different clades. The advantage offered by MF59 in terms of higher immunogenicity, expressed as higher post-vaccination HI titres, is observable also against viruses showing antigenic and molecular pattern undistinguishable from vaccine strain, but it became even more evident as the antigenic and molecular distance between vaccine and circulating strains grew. These data show that seasonal influenza vaccine adjuvanted with MF59 can offer a stronger benefit as compared to non-adjuvanted vaccine in protecting against a broader range of virus strains circulating during the influenza season.
KW - Cross-protection
KW - Influenza
KW - MF59
UR - http://www.scopus.com/inward/record.url?scp=77953125928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953125928&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.04.030
DO - 10.1016/j.vaccine.2010.04.030
M3 - Article
C2 - 20433807
AN - SCOPUS:77953125928
VL - 28
SP - 4123
EP - 4129
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 25
ER -