Antibody response to Helicobacter pylori CagA and heat-shock proteins in determining the risk of gastric cancer development

G. Iaquinto, A. Todisco, N. Giardullo, V. D'Onofrio, L. Pasquale, A. De Luca, A. Andriulli, F. Perri, C. Rega, G. De Chiara, M. Landi, W. Taccone, G. Leandro, N. Figura

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Objective. To investigate whether the systematic antibody response to Helicobacter pylori heat shock protein B can be considered, in addition to anti cytotoxin-associated protein [CagA] antibody determination, a further serological marker of increased risk of gastric cancer development. Methods. A total of 98 Giemsa positive Helicobacter pylori patients [28 with gastric cancer, 30 with doudenal ulcer and 40 with non-ulcer dyspepsia] were studied. Serum samples obtained from all patients were tested for lgG antibodies to CagA [116 kDa], VacA [89kDa] and heat skock protein B [54 kDa] antigens of Helicobacter pylori by the Western blot technique. Results. 26/28 patients [92.9%] with gastric carcinoma, 29/30 patients [96.7%] with doudenal ulcer and 30/40 patients [75.0%] with non-ulcer dyspepsia were seropositive for CagA protein. The prevalence of serum lgG antibody to CagA in the cancer patients was not significantly higher than in doudenal ulcer and non-ulcer dyspepsia patients. The prevalence of antibodies to VacA was not significantly different between gastric carcinoma and non-ulcer dyspepsia patients. In contrast the prevalence of systemic antibodies to heat skock protein B was significantly higher in gastric cancer patients [78.6%] than in doudenal ulcer [36.7%, p=0.002] or non-ulcer dyspepsia patients [52.5%, p=0.029]. Conclusions. The detection of antibodies to heat shock protein B is proposed as an additional test which, in association with the determination of serum antibodies to CagA, could help in determining the risk of developing severe gastroduodenal disease, and gastric cancer, in particular.

Original languageEnglish
Pages (from-to)378-383
Number of pages6
JournalDigestive and Liver Disease
Issue number5
Publication statusPublished - 2000


  • Gastric cancer
  • Heat shock protein
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology


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