Antibody response to hepatitis B vaccine in HIV-exposed infants in Malawi and correlation with HBV infection acquisition

Sandro Mancinelli, Maria F. Pirillo, Giuseppe Liotta, Mauro Andreotti, Robert Mphwere, Roberta Amici, Maria C. Marazzi, Stefano Vella, Leonardo Palombi, Marina Giuliano

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Abstract

The aim of this study was to assess the immune response to HBV vaccine in HIV-exposed infants and to correlate it to HBV infection acquisition. Protective anti-HBs levels (>10 mIU/mL) were found in 54/58 (93.2%) infants at 6 months, 126/144 (87.5%) at 12 months and 141/176 (80.1%) children at 24 months. HBV infection (seven children were HBsAg + at Month 24) occurred also in the presence of levels above 10 mIU/mL. Our findings indicate limited impact of HIV exposure on anti-HBV immune response, but suggest that levels >10 mIU/mL may be required to confer protection in this context.

Original languageEnglish
Pages (from-to)1172-1176
Number of pages5
JournalJournal of Medical Virology
Volume90
Issue number6
DOIs
Publication statusPublished - Jun 1 2018

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Keywords

  • HBV
  • HBV vaccine
  • HIV-exposed infants
  • sub-Saharan Africa

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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