Abstract
The Epstein-Barr virus BZLF1-encoded replication activator (ZEBRA) is a key mediate of reactivation from latency to the viral productive cycle. In the present study, the serum antibody responses against three defined ZEBRA epitopes (designated ZEBRA-1, -19, and -22) were determined for 50 human immunodeficiency virus (HIV)-seropositive patients and 100 matched healthy control subjects. The anti-ZEBRA responses were more commonly found among HIV-seropositive patients than among healthy controls for all the three ZEBRA epitopes tested (P <0.0003, P <0.003, and P <0.001, respectively). Comparison of ZEBRA antibody levels with the degree of immunodeficiency (CD4 cell counts), CDC grouping, and HIV p24 antigen positivity showed little association, suggesting that induction of ZEBRA antibodies is an early event after HIV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 363-364 |
| Number of pages | 2 |
| Journal | Clinical and Diagnostic Laboratory Immunology |
| Volume | 3 |
| Issue number | 3 |
| Publication status | Published - 1996 |
Fingerprint
ASJC Scopus subject areas
- Microbiology (medical)
- Immunology and Allergy
- Clinical Biochemistry
- Immunology
Cite this
Antibody responses to defined epitopes in the Epstein-Barr virus BZLF1-encoded transactivator protein among human immunodeficiency virus-infected patients. / Tedeschi, R.; Dillner, J.; De Paoli, P.
In: Clinical and Diagnostic Laboratory Immunology, Vol. 3, No. 3, 1996, p. 363-364.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibody responses to defined epitopes in the Epstein-Barr virus BZLF1-encoded transactivator protein among human immunodeficiency virus-infected patients
AU - Tedeschi, R.
AU - Dillner, J.
AU - De Paoli, P.
PY - 1996
Y1 - 1996
N2 - The Epstein-Barr virus BZLF1-encoded replication activator (ZEBRA) is a key mediate of reactivation from latency to the viral productive cycle. In the present study, the serum antibody responses against three defined ZEBRA epitopes (designated ZEBRA-1, -19, and -22) were determined for 50 human immunodeficiency virus (HIV)-seropositive patients and 100 matched healthy control subjects. The anti-ZEBRA responses were more commonly found among HIV-seropositive patients than among healthy controls for all the three ZEBRA epitopes tested (P <0.0003, P <0.003, and P <0.001, respectively). Comparison of ZEBRA antibody levels with the degree of immunodeficiency (CD4 cell counts), CDC grouping, and HIV p24 antigen positivity showed little association, suggesting that induction of ZEBRA antibodies is an early event after HIV infection.
AB - The Epstein-Barr virus BZLF1-encoded replication activator (ZEBRA) is a key mediate of reactivation from latency to the viral productive cycle. In the present study, the serum antibody responses against three defined ZEBRA epitopes (designated ZEBRA-1, -19, and -22) were determined for 50 human immunodeficiency virus (HIV)-seropositive patients and 100 matched healthy control subjects. The anti-ZEBRA responses were more commonly found among HIV-seropositive patients than among healthy controls for all the three ZEBRA epitopes tested (P <0.0003, P <0.003, and P <0.001, respectively). Comparison of ZEBRA antibody levels with the degree of immunodeficiency (CD4 cell counts), CDC grouping, and HIV p24 antigen positivity showed little association, suggesting that induction of ZEBRA antibodies is an early event after HIV infection.
UR - http://www.scopus.com/inward/record.url?scp=0030014634&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030014634&partnerID=8YFLogxK
M3 - Article
VL - 3
SP - 363
EP - 364
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
SN - 1071-412X
IS - 3
ER -