Antibody to hepatitis C virus after a vapour-heated factor VIII concentrate

P. M. Mannucci, A. R. Zanetti, M. Colombo, A. Chistolini, R. De Biasi, R. Musso, G. Tamponi

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To evaluate whether or not clotting factor concentrates exposed to virucidal procedures transmitted hepatitis C, sera obtained in 1984-1986 from 27 previously untreated hemophiliacs infused with a vapour-heated factor VIII concentrate were tested retrospectively for the antibody to the hepatitis C virus (anti-HCV). A 2-year-old hemophiliac, negative for anti-HCV before administration of concentrate, seroconverted at week 12 and remained anti-HCV positive thereafter. Both his parents were anti-HCV negative and he had no other household contact. The patient had also become HBsAg positive at week 8 and had at the same time a marked elevation of alanine aminotransferase. His double infection with the hepatitis B and C viruses indicates that hot vapour was not completely effective in inactiating these viruses.

Original languageEnglish
Pages (from-to)232-234
Number of pages3
JournalThrombosis and Haemostasis
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Hematology


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