Antibody transport and internalization into tumours

S. Matzku, G. Moldenhauer, H. Kalthoff, S. Canevari, M. Colnaghi, J. Schuhmacher, H. Bihl

Research output: Contribution to journalArticlepeer-review

Abstract

Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBritish Journal of Cancer
Volume62
Issue numberSUPPL. X
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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