Antibody transport and internalization into tumours

S. Matzku, G. Moldenhauer, H. Kalthoff, S. Canevari, M. Colnaghi, J. Schuhmacher, H. Bihl

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBritish Journal of Cancer
Volume62
Issue numberSUPPL. X
Publication statusPublished - 1990

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Radioisotopes
Monoclonal Antibodies
Antibodies
Neoplasms
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Matzku, S., Moldenhauer, G., Kalthoff, H., Canevari, S., Colnaghi, M., Schuhmacher, J., & Bihl, H. (1990). Antibody transport and internalization into tumours. British Journal of Cancer, 62(SUPPL. X), 1-5.

Antibody transport and internalization into tumours. / Matzku, S.; Moldenhauer, G.; Kalthoff, H.; Canevari, S.; Colnaghi, M.; Schuhmacher, J.; Bihl, H.

In: British Journal of Cancer, Vol. 62, No. SUPPL. X, 1990, p. 1-5.

Research output: Contribution to journalArticle

Matzku, S, Moldenhauer, G, Kalthoff, H, Canevari, S, Colnaghi, M, Schuhmacher, J & Bihl, H 1990, 'Antibody transport and internalization into tumours', British Journal of Cancer, vol. 62, no. SUPPL. X, pp. 1-5.
Matzku S, Moldenhauer G, Kalthoff H, Canevari S, Colnaghi M, Schuhmacher J et al. Antibody transport and internalization into tumours. British Journal of Cancer. 1990;62(SUPPL. X):1-5.
Matzku, S. ; Moldenhauer, G. ; Kalthoff, H. ; Canevari, S. ; Colnaghi, M. ; Schuhmacher, J. ; Bihl, H. / Antibody transport and internalization into tumours. In: British Journal of Cancer. 1990 ; Vol. 62, No. SUPPL. X. pp. 1-5.
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