Abstract
Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.
| Original language | English |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | British Journal of Cancer |
| Volume | 62 |
| Issue number | SUPPL. X |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Antibody transport and internalization into tumours. / Matzku, S.; Moldenhauer, G.; Kalthoff, H.; Canevari, S.; Colnaghi, M.; Schuhmacher, J.; Bihl, H.
In: British Journal of Cancer, Vol. 62, No. SUPPL. X, 1990, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibody transport and internalization into tumours
AU - Matzku, S.
AU - Moldenhauer, G.
AU - Kalthoff, H.
AU - Canevari, S.
AU - Colnaghi, M.
AU - Schuhmacher, J.
AU - Bihl, H.
PY - 1990
Y1 - 1990
N2 - Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.
AB - Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025369935&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 1
EP - 5
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - SUPPL. X
ER -