Antibody transport and internalization into tumours

S. Matzku; G. Moldenhauer; H. Kalthoff; S. Canevari; M. Colnaghi; J. Schuhmacher; H. Bihl

Antibody transport and internalization into tumours

S. Matzku, G. Moldenhauer, H. Kalthoff, S. Canevari, M. Colnaghi, J. Schuhmacher, H. Bihl

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	British Journal of Cancer
Volume	62
Issue number	SUPPL. X
Publication status	Published - 1990

ASJC Scopus subject areas

Cancer Research
Oncology

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abstract = "Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.",

author = "S. Matzku and G. Moldenhauer and H. Kalthoff and S. Canevari and M. Colnaghi and J. Schuhmacher and H. Bihl",

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AU - Moldenhauer, G.

AU - Kalthoff, H.

AU - Canevari, S.

AU - Colnaghi, M.

AU - Schuhmacher, J.

AU - Bihl, H.

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