Anticancer drug delivery with nanoparticles

Matteo Conti, Valeria Tazzari, Cesare Baccini, Gianni Pertici, Lorenzo Pio Serino, Ugo De Giorgi

Research output: Contribution to journalArticlepeer-review

Abstract

Nanotechnology provides a variety of nanoscale tools for medicine. Among them nanoparticles are revolutionizing the field of drug delivery. These drug nanocarriers have the potential to enhance the therapeutic efficacy of a drug, since they can be engineered to modulate the release and the stability and to prolong the circulation time of a drug, protecting it from elimination by phagocytic cells or premature degradation. Moreover, nanoscale carriers can be tailored to accumulate in tumour cells and tissues, due to enhanced permeability and a retention effect or by active targeting using ligands designed to recognize tumour-associated antigens. Could these nanomedicine tools mark an end to the necessity for loco-regional drug delivery?

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalIn Vivo
Volume20
Issue number6 A
Publication statusPublished - Nov 2006

Keywords

  • Drug deliver
  • Liposomes
  • Loco-regional delivery
  • Nanomedicine
  • Nanoparticles
  • Nanotechnology
  • Review
  • Toxicity

ASJC Scopus subject areas

  • Medicine(all)

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