Anticardiolopin antibodies in first-degree relatives of type 1, insulin- dependent, diabetic patients

Giuseppe D'Annunzio, Roberto Caporali, Carlomaurizio Montecucco, Letizia Vitali, Amalia Alibrandi, Paola Stroppa, Stefano Fiocchi, Renata Lorini

Research output: Contribution to journalArticlepeer-review


First-degree relatives (FDRs) of diabetic patients are at risk of IDDM, and frequently Present several autoantibodies. We Detected anticerdiolipin antibodies (aCL) in 42 FDRs, aged 12.4 ± 4.2 years and in 52 controls. aCL (IgG and IgM) were measured by ELISA and their results expressed in arbitrary units. All FDRs underwent islet cell antibodies (ICA) measurement, intravenous glucose tolerance test and HbA(1c) levels. HLA Typing and HLA-DQ molecular analysis were performed in all FDRs. Positive levels of aCL-IgG were observed in 8/42 FDRs and no control subject (p=0.04); aCL-IgM values were similar in FDRs and controls. No Correlation was Found between aCL levels and chronologic Age or HbA(1c) levels. No association was observed between aCL frequency and immunologic (ICA), metabollic or genetic (HLA) parameters. No FDR Showed and feature of antiphospholipid syndrome. aCL-IgC presence in FDRs is suggestive of a need to carry out of follow-up study to establish the significance of these methods.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number1
Publication statusPublished - 1998


  • Anticardiolipin antibodies
  • First-degree relatives
  • Insulin-dependent diabetes Mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health


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