Anticipation of age at onset of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder

Maria Cristina Cavallini, Monia Albertazzi, Laura Bianchi, Laura Bellodi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Anticipation of age at onset has been observed in several neuropsychiatric disorders. Recent studies have associated anticipation with the presence of unstable DNA and have suggested that trinucleotide repeats may be the main cause in some of these diseases. However, several selection biases may mimic the presence of such an effect. In this study we evaluated the presence of this effect in 40 families of probands with obsessive-compulsive disorder (OCD) compared with affected subjects in the parental generation. We controlled for ascertainment biases by taking into account the age at interview of probands. Using a different recruitment strategy, we controlled for anticipation in a sub-sample of offspring of 13 OCD patients, affected with OC spectrum disorders. While the younger generation showed a significantly earlier age at onset than the parental generation, no effect of age at interview was observed. Drawing on the results, we hypothesised that the presence of anticipation in OCD and OC spectrum disorders could be due to a specific genetic effect (unstable DNA), as it has been hypothesised for other disorders showing this effect.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalPsychiatry Research
Volume111
Issue number1
DOIs
Publication statusPublished - Aug 5 2002

Fingerprint

Obsessive-Compulsive Disorder
Age of Onset
Interviews
Trinucleotide Repeats
Cohort Effect
Selection Bias
DNA

Keywords

  • Anticipation
  • Genetics
  • Imprinting
  • Tic disorders
  • Unstable DNA

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Anticipation of age at onset of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder. / Cavallini, Maria Cristina; Albertazzi, Monia; Bianchi, Laura; Bellodi, Laura.

In: Psychiatry Research, Vol. 111, No. 1, 05.08.2002, p. 1-9.

Research output: Contribution to journalArticle

Cavallini, Maria Cristina ; Albertazzi, Monia ; Bianchi, Laura ; Bellodi, Laura. / Anticipation of age at onset of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder. In: Psychiatry Research. 2002 ; Vol. 111, No. 1. pp. 1-9.
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