TY - JOUR
T1 - Anticoagulant drugs in noncompaction
T2 - A mandatory therapy?
AU - Fazio, Giovanni
AU - Corrado, Giovanni
AU - Zachara, Elisabetta
AU - Rapezzi, Claudio
AU - Sulafa, Ali K.
AU - Sutera, Loredana
AU - Stollberger, Claudia
AU - Sormani, Luca
AU - Finsterer, Joseph
AU - Benatar, Abraham
AU - Di Gesaro, Gabriele
AU - Visconti, Claudia
AU - Dangelo, Luciana
AU - Novo, Giuseppina
AU - Mongiovi, Maurizio
AU - Cavusoglu, Yuksel
AU - Baumhakel, Magnus
AU - Drago, Fabrizio
AU - Indovina, Giuseppe
AU - Ferrara, Filippo
AU - Carerj, Scipione
AU - Pipitone, Salvatore
AU - Novo, Salvatore
PY - 2008/11
Y1 - 2008/11
N2 - BACKGROUND: Noncompaction of left ventricular myocardium is a rare congenital cardiomyopathy resulting from an incomplete myocardial morphogenesis that leads to the persistence of the embryonic myocardium. This condition is characterized by a thin compacted epicardial and an extremely thickened endocardial layer with prominent trabeculations and deep intertrabecular recesses. It is not clear, in noncompaction of myocardium, whether intertrabecular recesses could be responsible for thrombi formation and thromboembolic complications. METHODS: The prevalence of stroke and echocardiographic finding of thrombus was evaluated in a continuous series of 229 patients (men and women) affected by noncompaction of the left ventricular myocardium, who were included in the SIEC registry. We excluded patients affected by atrial fibrillation. RESULTS: The mean age of the patients was 49.5 years. Fifty percent of the patients were affected by a ventricular systolic dysfunction. The mean period of follow-up was 7.3 years. Only four patients had a history of ischemic stroke. A large thrombus into the left ventricular chamber was observed in a 1-year-old child affected by Behcet's disease (high risk of thrombi formation). CONCLUSION: Noncompaction of the left ventricular myocardium, by itself, does not seem to be a risk factor for stroke or embolic results, so there is no indication for oral anticoagulant therapy.
AB - BACKGROUND: Noncompaction of left ventricular myocardium is a rare congenital cardiomyopathy resulting from an incomplete myocardial morphogenesis that leads to the persistence of the embryonic myocardium. This condition is characterized by a thin compacted epicardial and an extremely thickened endocardial layer with prominent trabeculations and deep intertrabecular recesses. It is not clear, in noncompaction of myocardium, whether intertrabecular recesses could be responsible for thrombi formation and thromboembolic complications. METHODS: The prevalence of stroke and echocardiographic finding of thrombus was evaluated in a continuous series of 229 patients (men and women) affected by noncompaction of the left ventricular myocardium, who were included in the SIEC registry. We excluded patients affected by atrial fibrillation. RESULTS: The mean age of the patients was 49.5 years. Fifty percent of the patients were affected by a ventricular systolic dysfunction. The mean period of follow-up was 7.3 years. Only four patients had a history of ischemic stroke. A large thrombus into the left ventricular chamber was observed in a 1-year-old child affected by Behcet's disease (high risk of thrombi formation). CONCLUSION: Noncompaction of the left ventricular myocardium, by itself, does not seem to be a risk factor for stroke or embolic results, so there is no indication for oral anticoagulant therapy.
KW - Anticoagulant
KW - Embolism
KW - Ischemic stroke
KW - Isolated left ventricular noncompaction
KW - Thrombus
UR - http://www.scopus.com/inward/record.url?scp=58149396788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149396788&partnerID=8YFLogxK
U2 - 10.2459/JCM.0b013e328308da04
DO - 10.2459/JCM.0b013e328308da04
M3 - Article
C2 - 18852579
AN - SCOPUS:58149396788
VL - 9
SP - 1095
EP - 1097
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 11
ER -