Anticoagulation protocols for minimized cardiopulmonary bypass

Research output: Chapter in Book/Report/Conference proceedingChapter


The possible changes to the routine anticoagulation management that can be applied when using a mini-cardiopulmonary bypass circuit are described in this chapter. Mini-cardiopulmonary bypass circuits usually enable the reinfusion of shed blood to be avoided during the cardiac operation. Shed blood is the main source of tissue factor, which is in turn the major determinant of thrombin generation. Therefore, mini-cardiopulmonary bypass circuits may limit thrombin generation and consequently the need for large doses of heparin. Protocols based on reduction of systemic heparinization with specific monitoring of the anticoagulation are discussed.

Original languageEnglish
Title of host publicationMinimized Cardiopulmonary Bypass Techniques and Technologies
PublisherElsevier Inc.
Number of pages18
ISBN (Print)9781845698003
Publication statusPublished - Apr 2012


  • Activated clotting time
  • Cardiopulmonary bypass
  • Heparin
  • Thrombin
  • Tissue factor

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)


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