Antidegenerative effects of Mg2+-valproate in cultured cerebellar neurons

V. Bruno, M. A. Sortino, U. Scapagnini, F. Nicoletti, P. L. Canonico

Research output: Contribution to journal › Article › peer-review

Abstract

We have investigated in the present study the effect of Mg2+-valproate on necrotic degeneration induced by an excitotoxic insult in primary culture of cerebellar neurons, that is an homogeneous population of glutamatergic neurons. Mg2+-valproate protected cultures against glutamate-induced neurotoxicity, acting as an indirect N-methyl-D-aspartate (NMDA) receptor antagonist, thus reducing free radical formation and affecting the biochemical parameters (i.e. 45Ca2+-influx, cyclic GMP formation, inositol phospholipid hydrolysis and protein kinase C translocation) that undergo modifications following NMDA receptor activation in cerebellar granule cells.

Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalFunctional Neurology
Volume10
Issue number3
Publication statusPublished - 1995

Keywords

  • Cerebellar granule cells
  • Excitotoxicity
  • Glutamate
  • Mg-valproic acid

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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