Abstract
We have investigated in the present study the effect of Mg2+-valproate on necrotic degeneration induced by an excitotoxic insult in primary culture of cerebellar neurons, that is an homogeneous population of glutamatergic neurons. Mg2+-valproate protected cultures against glutamate-induced neurotoxicity, acting as an indirect N-methyl-D-aspartate (NMDA) receptor antagonist, thus reducing free radical formation and affecting the biochemical parameters (i.e. 45Ca2+-influx, cyclic GMP formation, inositol phospholipid hydrolysis and protein kinase C translocation) that undergo modifications following NMDA receptor activation in cerebellar granule cells.
Original language | English |
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Pages (from-to) | 121-130 |
Number of pages | 10 |
Journal | Functional Neurology |
Volume | 10 |
Issue number | 3 |
Publication status | Published - 1995 |
Keywords
- Cerebellar granule cells
- Excitotoxicity
- Glutamate
- Mg-valproic acid
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)