Antidepressant combination versus antidepressants plus second-generation antipsychotic augmentation in treatment-resistant unipolar depression

G Gobbi, MF Ghabrash, N Nuñez, J Tabaka, J Di Sante, M Saint-Laurent, S Vida, T Kolivakis, N Low, P Cervantes, L Booij, S Comai

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Abstract

Patients with treatment-resistant unipolar depression (TRD) are treated with antidepressant combinations (ADs) or with second-generation antipsychotics plus AD (SGA+AD) augmentation; however, the clinical characteristics, the factors associated independently with response to SGA+AD, and the outcome trajectories have not yet been characterized. We performed a naturalistic study on the latest stable trial (medication unchanged for about 3 months) in 86 TRD patients with resistance to at least two ADs trials, who received ADs (n=36) or SGA+AD (n=50) treatments. Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton-Depression Rating Scale (HAM-D17), and other scales were administered before (T0) and after the latest 3-month stable trial (T3). Compared to ADs, the SGA+AD group showed increased percentage of depression with psychotic features, comorbidity for personality disorders and substance use disorders (SUD), higher number of failed ADs pharmacotherapies and depressive symptoms at T0 on all scales (P
Original languageEnglish
Pages (from-to)34-43
Number of pages10
JournalInternational Clinical Psychopharmacology
Volume33
Issue number1
DOIs
Publication statusPublished - 2018

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    Gobbi, G., Ghabrash, MF., Nuñez, N., Tabaka, J., Di Sante, J., Saint-Laurent, M., Vida, S., Kolivakis, T., Low, N., Cervantes, P., Booij, L., & Comai, S. (2018). Antidepressant combination versus antidepressants plus second-generation antipsychotic augmentation in treatment-resistant unipolar depression. International Clinical Psychopharmacology, 33(1), 34-43. https://doi.org/10.1097/YIC.0000000000000196