Abstract
CaM kinase II, a regulator of synaptic plasticity, is implicated in pathophysiology and pharmacology of psychiatric disorders. Chronic treatment with antidepressants desipramine and reboxetine up-regulated CaM kinase II in neuronal cell bodies of hippocampus. mRNA/protein expression for αCaM kinase II was unchanged, whereas Thr286 phosphorylation was increased in pyramidal/granular cell bodies, suggesting that increased phosphorylation is responsible for kinase activation. Short-term treatment of neuronal cultures with reboxetine reduced kinase activation in a concentration-dependent manner. The short-term inhibitory effect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation.
| Original language | English |
|---|---|
| Pages (from-to) | 2393-2396 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 15 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - Oct 25 2004 |
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Keywords
- Antidepressant
- CaM kinase II
- Hippocampus
- Neuroplasticity
- Phosphorylation
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation. / Tiraboschi, Ettore; Giambelli, Roberto; D'Urso, Giordano; Galietta, Antonio; Barbon, Alessandro; De Bartolomeis, Andrea; Gennarelli, Massimo; Barlati, Sergio; Racagni, Giorgio; Popoli, Maurizio.
In: NeuroReport, Vol. 15, No. 15, 25.10.2004, p. 2393-2396.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation
AU - Tiraboschi, Ettore
AU - Giambelli, Roberto
AU - D'Urso, Giordano
AU - Galietta, Antonio
AU - Barbon, Alessandro
AU - De Bartolomeis, Andrea
AU - Gennarelli, Massimo
AU - Barlati, Sergio
AU - Racagni, Giorgio
AU - Popoli, Maurizio
PY - 2004/10/25
Y1 - 2004/10/25
N2 - CaM kinase II, a regulator of synaptic plasticity, is implicated in pathophysiology and pharmacology of psychiatric disorders. Chronic treatment with antidepressants desipramine and reboxetine up-regulated CaM kinase II in neuronal cell bodies of hippocampus. mRNA/protein expression for αCaM kinase II was unchanged, whereas Thr286 phosphorylation was increased in pyramidal/granular cell bodies, suggesting that increased phosphorylation is responsible for kinase activation. Short-term treatment of neuronal cultures with reboxetine reduced kinase activation in a concentration-dependent manner. The short-term inhibitory effect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation.
AB - CaM kinase II, a regulator of synaptic plasticity, is implicated in pathophysiology and pharmacology of psychiatric disorders. Chronic treatment with antidepressants desipramine and reboxetine up-regulated CaM kinase II in neuronal cell bodies of hippocampus. mRNA/protein expression for αCaM kinase II was unchanged, whereas Thr286 phosphorylation was increased in pyramidal/granular cell bodies, suggesting that increased phosphorylation is responsible for kinase activation. Short-term treatment of neuronal cultures with reboxetine reduced kinase activation in a concentration-dependent manner. The short-term inhibitory effect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation.
KW - Antidepressant
KW - CaM kinase II
KW - Hippocampus
KW - Neuroplasticity
KW - Phosphorylation
UR - http://www.scopus.com/inward/record.url?scp=8444252964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8444252964&partnerID=8YFLogxK
U2 - 10.1097/00001756-200410250-00018
DO - 10.1097/00001756-200410250-00018
M3 - Article
C2 - 15640762
AN - SCOPUS:8444252964
VL - 15
SP - 2393
EP - 2396
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 15
ER -