Antidepressants for cancer pain and other painful syndromes with deafferentation component: comparison of Amitriptyline and Trazodone

V. Ventafridda, C. Bonezzi, A. Caraceni, F. De Conno, G. Guarise, G. Ramella, L. Saita, V. Silvani, M. Tamburini, F. Toscani

Research output: Contribution to journalArticle

Abstract

The Authors report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic cancer pain with deafferentation component. Fortyfive patients were admitted to the study: 27 with oncological peripheral nerve lesions, 6 with post herpetic neuralgias, 10 with not oncological nerve lesions, 2 with central nervous lesions. Almost all of them were already being treated with NSAID associated with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitryptiline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety, weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.

Original languageEnglish
Pages (from-to)579-587
Number of pages9
JournalItalian Journal of Neurological Sciences
Volume8
Issue number6
DOIs
Publication statusPublished - Dec 1987

Keywords

  • antidepressants
  • Cancer pain
  • deafferentation pain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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