Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives

Grazia Daniela Femminella, Leonardo Bencivenga, Laura Petraglia, Lucia Visaggi, Lucia Gioia, Fabrizio Vincenzo Grieco, Claudio De Lucia, Klara Komici, Graziamaria Corbi, Paul Edison, Giuseppe Rengo, Nicola Ferrara

Research output: Contribution to journalReview articlepeer-review

Abstract

Diabetes mellitus (DM) and Alzheimer's disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results. Here, we review the evidence on the mechanisms of action of antidiabetic drugs and their potential use in AD.

Original languageEnglish
Pages (from-to)7420796
JournalJournal of Diabetes Research
Volume2017
DOIs
Publication statusPublished - 2017

Keywords

  • Journal Article
  • Review

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