Antiemetic prophylaxis in patients undergoing hematopoietic stem cell transplantation: a multicenter survey of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) transplant programs.

Domenico Pastore, Benedetto Bruno, Paola Carluccio, Maria Stella De Candia, Sonia Mammoliti, Carlo Borghero, Anna Chierichini, Fabio Pavan, Marco Casini, Massimo Pini, Luca Nassi, Raffaella Greco, Francesco Paolo Tambaro, Paola Stefanoni, Giuseppe Console, Francesco Marchesi, Luca Facchini, Alberto Mussetti, Michele Cimminiello, Francesco SaglioDaniele Vincenti, Sadia Falcioni, Patrizia Chiusolo, Jacopo Olivieri, Annalisa Natale, Maura Faraci, Simone Cesaro, Serena Marotta, Anna Proia, Irene Donnini, Daniela Caravelli, Eliana Zuffa, Anna Paola Iori, Elena Soncini, Valentina Bozzoli, Giovanni Pisapia, Renato Scalone, Oreste Villani, Arcangelo Prete, Antonella Ferrari, Mariacristina Menconi, Giorgia Mancini, Federica Gigli, Gianpaolo Gargiulo, Barbara Bruno, Francesca Patriarca, Francesca Bonifazi

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A survey within hematopoietic stem cell transplant (HSCT) centers of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) was performed in order to describe current antiemetic prophylaxis in patients undergoing HSCT. The multicenter survey was performed by a questionnaire, covering the main areas on chemotherapy-induced nausea and vomiting (CINV): antiemetic prophylaxis guidelines used, antiemetic prophylaxis in different conditioning regimens, and methods of CINV evaluation. The survey was carried out in November 2016, and it was repeated 6 months after the publication of the Multinational Association of Supportive Care in Cancer (MASCC)/European Society for Medical Oncology (ESMO) specific guidelines on antiemetic prophylaxis in HSCT. The results show a remarkable heterogeneity of prophylaxis among the various centers and a significant difference between the guidelines and the clinical practice. In the main conditioning regimens, the combination of a serotonin receptor antagonist (5-HT -RA) with dexamethasone and neurokin receptor antagonist (NK1-RA), as recommended by MASCC/ESMO guidelines, increased from 0 to 15% (before the publication of the guidelines) to 9-30% (after the publication of the guidelines). This study shows a lack of compliance with specific antiemetic guidelines, resulting mainly in under-prophylaxis. Concerted strategies are required to improve the current CINV prophylaxis, to draft shared common guidelines, and to increase the knowledge and the adherence to the current recommendations for CINV prophylaxis in the specific field of HSCT.
Original languageUndefined/Unknown
Pages (from-to)867-875
Number of pages9
JournalAnnals of Hematology
Publication statusPublished - Apr 1 2020


  • Allografts
  • Antiemetics
  • therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols
  • adverse effects
  • Guideline Adherence
  • Health Care Surveys
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Italy
  • Myeloablative Agonists
  • Nausea
  • chemically induced
  • prevention & control
  • Practice Guidelines as Topic
  • Practice Patterns
  • Physicians'
  • statistics & numerical data
  • Transplantation Conditioning
  • Transplantation
  • Autologous
  • Vomiting
  • Antiemetic prophylaxis
  • CINV
  • Hematopoietic stem cell transplantation
  • MASCC/ESMO guidelines

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