Antiendomysial and antigliadin antibodies in patients with Down syndrome

B. Papadatou, A. Crinò, A. Giannotti, F. Ferretti, F. Colistro, M. C. Digilio, P. Ciampalini, V. Lucidi, P. Borelli, M. Castro

Research output: Contribution to journalArticlepeer-review


The association of celiac disease (CD) and Down syndrome (DS) is reported by various authors. It is often an atypical form of CD without diarrhea, thus screening tests for CD are of primary importance in selecting DS patients who should undergo jejunal biopsies. IgA-antigliadin antibodies (IgA-AGA) and antiendomysial antibodies (AEA) were assessed in 150 children with DS. In 23% only high IgA-AGA levels were found, in 4% only AEA were present and in 8% both tests were positive. Thirty-four patients out of 53 with high AGA levels and/or AEA positivity underwent jejunal biopsy. Total villous atrophy was found in 14 (41%) patients. Both tests were positive in 72% of patients with CD and in 1 patient with normal mucosa. AEA alone was detected in 1 patient with normal mucosa, whereas high IgA-AGA levels were found in 18 out of 20 (90%) patients with DS with normal jejunal mucosa.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalDevelopmental Brain Dysfunction
Issue number2-3
Publication statusPublished - 1996


  • Antiendomysial antibodies
  • Antigliadin antibodies
  • Celiac disease
  • Down syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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