Antiendothelial Cell Antibodies

Nicoletta Ronda, Elena Raschi, Maria O. Borghi, Pier Luigi Meroni

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Antiendothelial cell antibodies (AECA) are a family of autoantibodies able to react with endothelial cells (EC), which differ from each other for antigen specificity, ability to bind to surface or intracellular structures, and functional effects. Natural AECA exist, display in vitro anti-inflammatory action on EC, and probably contribute to the therapeutic activity of high-dose intravenous immunoglobulins (IVIG) in several systemic inflammatory disorders. Pathologic AECA are produced in abnormal amount and composition during many diseases associated with endothelial perturbation. Various assays have been developed to detect and study pathologic AECA for both clinical and experimental investigations. The pathogenic role of AECA is suggested by both experimental evidence and clinical data: AECA are able to induce proinflammatory and procoagulant properties in EC and to cause various disease manifestations in animal models. AECA prevalence and specificity seem to be specific for the single diseases and their circulating levels sometimes vary with disease activity. The identification of antigens recognized in single diseases is crucial to improve diagnostic and prognostic relevance of AECA detection and obtain detailed information on their mechanisms of action.

Original languageEnglish
Title of host publicationAutoantibodies: Third Edition
PublisherElsevier B.V.
Pages723-729
Number of pages7
ISBN (Print)9780444563781
DOIs
Publication statusPublished - Dec 2013

Keywords

  • AECA antigens
  • AECA assays
  • Antiendothelial antibodies
  • Natural AECA
  • Pathogenic AECA

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Antiendothelial Cell Antibodies'. Together they form a unique fingerprint.

Cite this