Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock

Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Federico Mocchegiani, Claudio Viticchi, Fiorenza Orlando, Giuseppina D'Amato, Maria Simona Del Prete, Wojciech Kamysz, Jerzy łLukasiak, Vittorio Saba, Giorgio Scalise

Research output: Contribution to journalArticle

Abstract

The therapeutic efficacy of protegrin peptide IB-367 was investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 1mg Escherichia coli 0111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2×1010CFU of E. coli ATCC 25922, and (iii) rats in which intra-abdominal sepsis was induced via cecal ligation and puncture. All animals were randomized to receive parenterally isotonic sodium chloride solution, 1mg/kg of IB-367, 60mg/kg piperacillin and 1mg/kg of IB-367 plus 60mg/kg piperacillin. The peptide demonstrated lower level of antimicrobial activity than piperacillin, nevertheless it exhibited the dual properties of antimicrobial and antiendotoxin agent. Finally IB-367 and piperacillin association showed to be the most effective therapeutic approach.

Original languageEnglish
Pages (from-to)1747-1752
Number of pages6
JournalPeptides
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Antimicrobial peptides
  • Endotoxin
  • IB-367
  • Lipopolysaccharide
  • Protegrins
  • Septic shock

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Giacometti, A., Cirioni, O., Ghiselli, R., Mocchegiani, F., Viticchi, C., Orlando, F., D'Amato, G., Del Prete, M. S., Kamysz, W., łLukasiak, J., Saba, V., & Scalise, G. (2003). Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock. Peptides, 24(11), 1747-1752. https://doi.org/10.1016/j.peptides.2003.07.027