Antiepileptic drug therapy and plasma levels in 2500 patients from Northern Italy.

P. Zagnoni, L. Leone, A. Baruzzi, E. Benassi, M. De Bernardi, G. M. Frigo, P. C. Gerbino-Promis, G. Zaccara

Research output: Contribution to journalArticle

Abstract

The antiepileptic drug therapy of 1912 patients coming from various neurological clinics of Northern Italy has been evaluated in a collaborative survey. The following epidemiological data have been analysed: incidence of the various seizures types, according to the International Classification (Gastaut, 1969), in relation to the age; drug choice and therapeutic schedules in relation to the seizure type and to the age; number of drugs administered in various age and seizure groups; side effects in relation to type, number and plasma concentrations of the administered drugs. The analysis of the drug plasma level determinations, carried out either with gas-chromatographic methods or with the EMIT system, was effected in order to evaluate the number of patients who were under, in or over the suggested therapeutic ranges, the influence of age on drug disposition and the modifications of the drug plasma levels due to drug interactions.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalMonographs in neural sciences
Volume5
Publication statusPublished - 1980

Fingerprint

Anticonvulsants
Italy
Drug Therapy
Pharmaceutical Preparations
Seizures
Drug Interactions
Appointments and Schedules
Age Groups
Gases
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zagnoni, P., Leone, L., Baruzzi, A., Benassi, E., De Bernardi, M., Frigo, G. M., ... Zaccara, G. (1980). Antiepileptic drug therapy and plasma levels in 2500 patients from Northern Italy. Monographs in neural sciences, 5, 183-189.

Antiepileptic drug therapy and plasma levels in 2500 patients from Northern Italy. / Zagnoni, P.; Leone, L.; Baruzzi, A.; Benassi, E.; De Bernardi, M.; Frigo, G. M.; Gerbino-Promis, P. C.; Zaccara, G.

In: Monographs in neural sciences, Vol. 5, 1980, p. 183-189.

Research output: Contribution to journalArticle

Zagnoni, P, Leone, L, Baruzzi, A, Benassi, E, De Bernardi, M, Frigo, GM, Gerbino-Promis, PC & Zaccara, G 1980, 'Antiepileptic drug therapy and plasma levels in 2500 patients from Northern Italy.', Monographs in neural sciences, vol. 5, pp. 183-189.
Zagnoni P, Leone L, Baruzzi A, Benassi E, De Bernardi M, Frigo GM et al. Antiepileptic drug therapy and plasma levels in 2500 patients from Northern Italy. Monographs in neural sciences. 1980;5:183-189.
Zagnoni, P. ; Leone, L. ; Baruzzi, A. ; Benassi, E. ; De Bernardi, M. ; Frigo, G. M. ; Gerbino-Promis, P. C. ; Zaccara, G. / Antiepileptic drug therapy and plasma levels in 2500 patients from Northern Italy. In: Monographs in neural sciences. 1980 ; Vol. 5. pp. 183-189.
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