TY - JOUR
T1 - Antiepileptic drug therapy and plasma levels in 2500 patients from Northern Italy.
AU - Zagnoni, P.
AU - Leone, L.
AU - Baruzzi, A.
AU - Benassi, E.
AU - De Bernardi, M.
AU - Frigo, G. M.
AU - Gerbino-Promis, P. C.
AU - Zaccara, G.
PY - 1980
Y1 - 1980
N2 - The antiepileptic drug therapy of 1912 patients coming from various neurological clinics of Northern Italy has been evaluated in a collaborative survey. The following epidemiological data have been analysed: incidence of the various seizures types, according to the International Classification (Gastaut, 1969), in relation to the age; drug choice and therapeutic schedules in relation to the seizure type and to the age; number of drugs administered in various age and seizure groups; side effects in relation to type, number and plasma concentrations of the administered drugs. The analysis of the drug plasma level determinations, carried out either with gas-chromatographic methods or with the EMIT system, was effected in order to evaluate the number of patients who were under, in or over the suggested therapeutic ranges, the influence of age on drug disposition and the modifications of the drug plasma levels due to drug interactions.
AB - The antiepileptic drug therapy of 1912 patients coming from various neurological clinics of Northern Italy has been evaluated in a collaborative survey. The following epidemiological data have been analysed: incidence of the various seizures types, according to the International Classification (Gastaut, 1969), in relation to the age; drug choice and therapeutic schedules in relation to the seizure type and to the age; number of drugs administered in various age and seizure groups; side effects in relation to type, number and plasma concentrations of the administered drugs. The analysis of the drug plasma level determinations, carried out either with gas-chromatographic methods or with the EMIT system, was effected in order to evaluate the number of patients who were under, in or over the suggested therapeutic ranges, the influence of age on drug disposition and the modifications of the drug plasma levels due to drug interactions.
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M3 - Article
C2 - 7322152
AN - SCOPUS:0019235888
VL - 5
SP - 183
EP - 189
JO - Monographs in neural sciences
JF - Monographs in neural sciences
SN - 0300-5186
ER -