Antiepileptic drug therapy: Does mechanism of action matter?

Martin J. Brodie, Athanasios Covanis, Antonio Gil-Nagel, Holger Lerche, Emilio Perucca, Graeme J. Sills, H. Steve White

Research output: Contribution to journalArticle

Abstract

This article represents a synthesis of presentations made by the authors during a scientific meeting held in London on 7 June 2010 and organized by GlaxoSmithKline. Each speaker produced a short précis of his lecture to answer a specific question, resulting in an overview of what we know about the relevance of the mechanisms of action of antiepileptic drugs in determining appropriate combination therapies for the treatment of drug-resistant epilepsy.

Original languageEnglish
Pages (from-to)331-341
Number of pages11
JournalEpilepsy and Behavior
Volume21
Issue number4
DOIs
Publication statusPublished - Aug 2011

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Keywords

  • Antiepileptic drugs
  • Antiepileptogenesis
  • Disease modification
  • Epilepsy
  • Epileptogenesis
  • Interactions
  • Mechanism of action
  • Pharmacodynamics
  • Pharmacokinetics
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Brodie, M. J., Covanis, A., Gil-Nagel, A., Lerche, H., Perucca, E., Sills, G. J., & White, H. S. (2011). Antiepileptic drug therapy: Does mechanism of action matter? Epilepsy and Behavior, 21(4), 331-341. https://doi.org/10.1016/j.yebeh.2011.05.025